L-Glutamic acid
L-Glutamic acid is probably an excitatory transmitter of major significance in the mammalian central nervous system. L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Nature, 1974 , 248 (5451) :804-5.
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid[Reference:
WebLink]
L-Glutamic acid is probably an excitatory transmitter of major significance in the mammalian central nervous system1.
METHODS AND RESULTS:
The L-Glutamic acid molecule is relatively flexible, and in an attempt to gain some insight into its possible shape(s) during activation of receptors associated with excitation of central neurones, a study was made of four conformationally restricted analogues: (±)-cis-1-aminocyclohexane-1,3-dicarboxylic acid (‘cyclo-glutamic’ acid), ibotenic acid, kainic acid and its dihydro derivative.
Bioconjug. Chem., 1999 , 10 (1) :137-40.
L-Glutamic acid and L-lysine as useful building blocks for the preparation of bifunctional DTPA-like ligands.[Reference:
WebLink]
METHODS AND RESULTS:
Bisalkylation of suitably protected L-Glutamic acid and L-lysine derivatives with tert-butyl N-(2-bromoethyl)iminodiacetate 2, followed by deprotection of the omega functional group affords N, N-bis[2-[bis[2-(1, 1-dimethylethoxy)-2-oxoethyl]amino]ethyl]-L-Glutamic acid 1-(1, 1-dimethylethyl) ester 4 and N2,N2-bis[2-[bis[2-(1, 1-dimethylethoxy)-2-oxoethyl]amino]ethyl]-L-lysine 1,1-dimethylethyl ester 7. Such compounds feature a carboxylic or an amino group, respectively, which are available for conjugation with a suitable partner via formation of an amide bond. The conjugates, which can be prepared in this way, contain a chelating subunit in which all five acetic residues of DTPA are available for the complexation of metal ions. Direct bisalkylation of glycine with 2 promptly gives N, N-bis[2-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]ethyl]glycine 11.
CONCLUSIONS:
The latter allows to achieve conjugates in which the central acetic group of DTPA is selectively converted into an acetamide.
