L-Canavanine sulfate
The ingestion of an excess of alfalfa sprouts may induce systemic lupus erythematosus (SLE).
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Nutritional Immunology, 2008, 5(3):17-27.
Does L-Canavanine Ingestion Induce Murine SLE?[Reference:
WebLink]
Observations in humans and macaques suggest that ingestion of an excess of alfalfa sprouts can induce systemic lupus erythematosus (SLE). Feeding L-canavanine increased the incidence of autoimmune symptoms in several strains of mice. The presence of L-canavanine in alfalfa sprouts could result in the synthesis of proteins rich in L-canavanyl residues and subsequent recognition of these modified endogenous proteins as foreign.
METHODS AND RESULTS:
The original purpose of this long-term study in BALB/c mice was to determine whether ingestion of L-canavanine did induce an SLE-like disorder by such a mechanism. Analysis of mortality patterns observed during that investigation of diet-induced autoimmune disease suggests that L-canavanine increases murine longevity. Eighteen female BALB/c mice were fed a diet containing 1.56% L-Canavanine sulfate (equivalent to 1% L-canavanine base). Eighteen other mice received a control diet. The animals were monitored for the presence of anti-nucleic acids and survival. There was no evidence of anti-nucleic acid antibodies. However, 50% of control mice, compared with only 11% of canavanine-fed mice, died before 477 days of age (P < 0.05).
CONCLUSIONS:
Full life span studies of the effects of L-canavanine, with larger groups of mice from a variety of strains should be done to verify whether dietary L-canavanine is an alternative to nutrient restriction for increasing the life span of mice.
