Kadsuracoccinic acid A
Kadsuracoccinic acid A has anticancer activity, it induces significant cleavage arrest. Kadsuracoccinic acid A may be related to the preservation of the progression of the M phase.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Nat Prod. 2008 Apr;71(4):739-41.
Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis.[Pubmed:
18271558]
METHODS AND RESULTS:
Three new 3,4- seco-lanostanes, Kadsuracoccinic acid A - C ( 1- 3), were isolated from the medicinal plant Kadsura coccinea, in addition to the known compounds kadsuric acid ( 4) and micranoic acid A ( 5). The structures of 1- 3 were elucidated by analysis of their 2D-NMR spectroscopic data. Furthermore, the relative conformation of 1 was confirmed by an X-ray crystallographic study.
CONCLUSIONS:
This is the first report of a 3,4- seco-lanostane-type triterpene with a 17(20)-ene functional group.
Treatment of cultured individual Xenopus laevis cells with 1 at the blastular stage arrested cleavage of these cells with an IC 50 of 0.32 microg/mL.
