Isoelemicin

Isoelemicin
Product Name Isoelemicin
CAS No.: 5273-85-8
Catalog No.: CFN97886
Molecular Formula: C12H16O3
Molecular Weight: 208.3 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: Oil
Source: The herbs of Erythrina stricta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Reference standards.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Drug Chem Toxicol.2024,1-12.
  • Food Bioscience2022, 50:102187.
  • J Pharm Pharmacol.2022, rgac033.
  • Food Funct.2022, 13(13):6923-6933.
  • J Agric Food Chem.2023, 71(47):18510-18523.
  • Int J Mol Sci.2020, 21(19):7209.
  • FEBS J.2022, 10.1111:febs.16676.
  • Molecules.2023, 28(3):1313.
  • J Physiol Biochem.2024, 80(2):421-437.
  • Toxicol Rep.2021, 8:1131-1142.
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    METHODS AND RESULTS:
    1. The metabolites of elemicin (3,4,5-trimethoxyallylbenzene) and Isoelemicin (3,4,5-trimethoxypropenylbenzene) in the rat were identified by g.l.c.-mass spectrometry. 2. The major metabolic reactions of elemicin follow the cinnamoyl pathway or the epoxide-diol pathway. The former route gives 3-(3,4,5-trimethoxyphenyl)propionic acid and its glycine conjugate as major urinary metabolites, whereas 3-(3,4,5-trimethoxyphenyl)propane-1,2-diol is the most prominent metabolite of the latter route. Small amounts of the epoxide of the 3-O-demethylated derivative of elemicin were identified in the urine. 3. Isoelemicin was metabolized by both aforementioned pathways; the cinnamoyl pathway predominated and 3-(3,4,5-trimethoxyphenyl)propionic acid was the major urinary metabolite.
    CONCLUSIONS:
    4. All of the acidic metabolites detected were C6--C3 derivatives and further oxidation to benzoic acid derivatives did not occur. 5. Most of the urinary metabolites were also found in the bile, but in different relative amounts.
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