Hispidone
Hispidone shows potent cytotoxic activity against P388 and KB cells.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Toxicol Mech Methods.2021, 1-12.
Int J Mol Sci.2017, 18(5)
Biomed Pharmacother.2024, 179:117395.
Molecules.2021, 26(6):1635.
Food Chem.2018, 252:207-214
Int J Mol Sci.2021, 22(14):7324.
Asian Pac J Cancer Prev. 2020, 21(4):935-941.
FEBS Lett.2021, 595(20):2608-2615.
National University of Pharmacy2022, 1:73-76
J Food Biochem.2021, 45(7):e13774.
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Chemical & Pharmaceutical Bulletin, 1992 ,40 (4) :1053-5.
Cytotoxic Quassinoids and Tirucallane-Type Triterpenes from the Woods of Eurycoma longifolia.[Reference:
WebLink]
METHODS AND RESULTS:
New cytostatic quassinoids, 6α-hydroxyeurycomalactone (1), longilactone (2) and 14, 15β-dihydroxyklaineanone (3) were isolated from the woods of Eurycoma longifolia (Simaroubaceae) with three cytotoxic quassinoids, 11-dehydroklaineanone (4), eurycomalactone (5) and 5, 6-dehydroeurycomalactone (6), and with seven cytotoxic tirucallane-type triterpenes, niloticin (7), dihydroniloticin (8), piscidinol A (9), bourjotinolone A (10), 3-episapelin A (11), melianone (12) and Hispidone (13).
CONCLUSIONS:
All of them showed potent cytotoxic activity against P388 and KB cells.
Chem Pharm Bull (Tokyo). 2003 Apr;51(4):412-4.
Cholinesterase inhibitory constituents from Onosma hispida.[Pubmed:
12672994]
METHODS AND RESULTS:
Hispidone, a new flavanone, has been isolated from Onosma hispida and assigned the structure (2S)-5,2'-dihydroxy-7,4',5'-trimethoxyflavanone (1) by spectroscopic methods. In addition, (2S)-5,2'-dihydroxy-7,5'-dimethoxyflavanone (2), benzoic acid (3), and 4-hydroxy benzoic acid (4) are also reported for the first time from this species.
