Hebeirubescensin H
Hebeirubescensin H is a natural product from Isodon parvifolius.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
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Tetrahedron, 2006, 62(20):4941-4947.
Cytotoxic ent-kauranoid derivatives from Isodon rubescens.[Reference:
WebLink]
METHODS AND RESULTS:
An extensive study of the diterpenoids produced by the species of Isodon rubescens , has led to the isolation of 12 new ent -kaurane diterpenoids, hebeirubescensin A,Hebeirubescensin B, Hebeirubescensin C,Hebeirubescensin D, Hebeirubescensin E, Hebeirubescensin F, Hebeirubescensin G, Hebeirubescensin H, Hebeirubescensin I, Hebeirubescensin J, Hebeirubescensin K,Hebeirubescensin L ( 1 – 12 ), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells.
CONCLUSIONS:
Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC 50 values of <2.002μM. The structure–activity relationships were discussed.
