Guan-fu base A

Guan-fu base A
Product Name Guan-fu base A
CAS No.: 1394-48-5
Catalog No.: CFN91495
Molecular Formula: C24H31NO6
Molecular Weight: 429.5 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Aconitum coreanum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current. IC50 & Target:CYP2D6 HERG channel
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Food Sci.2022, 87(11):4905-4916.
  • Food Chem.2021, 360:130063.
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Journal of Functional Foods2021, 84:104581
  • Oxid Med Cell Longev.2021, 2021:6647107.
  • Analytical methods2019, 11(6)
  • Biochem Pharmacol. 2020, 177:114014.
  • Phytomedicine.2018, 41:62-66
  • Phytomedicine.2023, 116:154841.
  • Metabolites.2019, 9(11):E271
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