Epifriedelanol

Planta Med. 2011 Mar;77(5):441-9.

Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cells.[Pubmed: 21049397]

Among twenty-two compounds isolated, Epifriedelanol (3), ssioriside (15), and catechin-7-O- β-D-glucopyranoside (22) had inhibitory effects on adriamycin-induced cellular senescence in HDFs. Friedelin (2), Epifriedelanol (3), and catechin-7-O- β-apiofuranoside (18) were active in HUVECs. In particular, Epifriedelanol (3) suppressed adriamycin-induced cellular senescence as well as replicative senescence in HDFs and HUVECs. These results suggest that Epifriedelanol (3) reduces cellular senescence in human primary cells and might be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.

Fitoterapia. 2000 Sep;71(5):577-9.

Antitumor activity of epifriedelanol from Vitis trifolia.[Pubmed: 11449513]

The isolation and NMR spectral data of Epifriedelanol from Vitis trifolia are reported. It demonstrated antitumor activity in a potato disc bioassay.

Lat. Am. J. Pharm., 2015, 34(2):291-5.

Bioactive Constituents from the Rhizomes of Aster tataricus L. f. Afford the Treatment of Asthma through Activation of beta(2)AR and Inhibition of NF-kappa b[Reference: WebLink]

The rhizomes of Aster tataricus L. f. are used as materia medica or prescriptions for the treatment of asthma in Chinese folklore.
METHODS AND RESULTS:
To elucidate the mechanism of asthma treatment by A. tataricus, chemical constituents of this plant have been studied and screening for inhibiting NF-kappa B and activating beta(2) adrenergic receptor of relevant compounds has been performed by dual luciferase reporter assays. As a result, 10 natural compounds have been identified from rhizomes of A. tataricus including beta-sitosterol (1), daucosterol (2), kaempferol (3), quercetin (4), shionone (5), friedelin (6), Epifriedelanol (7), atersaponin A (8), aurantiamide (9), and astin C (10).
CONCLUSIONS:
Of all the 10 compounds obtained, 3, 9 and 10 showed activation of beta(2) adrenergic receptor and 3-9 exhibited significant inhibition of NF-kappa B, which could present evidences of A. tataricus for the treatment of asthma.

Pharm Biol. 2015 Jan 22:1-5.

Potent protein tyrosine phosphatase 1B (PTP1B) inhibiting constituents from Anoectochilus chapaensis and molecular docking studies.[Pubmed: 25609152]

Anoectochilus chapaensis Gagnep. (Orchidaceae), an indigenous and valuable Chinese folk medicine, has been used as an antidiabetic remedy. However, the bioactive constituents have not been reported. To explore potent protein tyrosine phosphatase 1B (PTP1B) inhibitors from the whole herbs of A. chapaensis for the treatment of diabetes.
METHODS AND RESULTS:
The compounds were obtained by PTP1B bioactivity-guided isolation from the active fraction of ethonal extract of A. chapaensis, and elucidated by extensive spectroscopic methods and evaluated for their potential to inhibit PTP1B with a series of doses in dimethyl sulphoxide by a colorimetric assay in vitro. The Autodock program was used to dock the active compounds into the binding sites. Fifteen compounds were identified; Epifriedelanol, friedelane, 2α, 3β-dihydroxyolean-12-en-23, 28, 30-trioic acid, dibutyl-phthalate, and 7-hydroxy-2-methoxy-9,10-dihydrophenanthrene-1,4-dione were isolated from the genera Anoectochilus for the first time. All 15 compounds were tested for their inhibitory activity against PTP1B in vitro. Nine active compounds exhibited potent inhibitory effect with IC50 values of 1.16-6.21 μM, which were comparable with the positive control suramin. The 3D-docking simulations showed negative binding energies of -7.4 to -8.5 kcal/mol and supported a high affinity to PTP1B residues in the pocket site, indicating that they may stabilize the open form and generate tighter binding to the catalytic sites of PTP1B.
CONCLUSIONS:
The results clearly demonstrated that the potential active constituents from A. chapaensis could inhibit PTP1B, which may be mainly attributed to a combination of triterpenoids and flavonoids.

J Asian Nat Prod Res. 2013 Sep;15(9):1050-4.

A new cycloartane nortriterpenoid from stem and leaf of Quercus variabilis.[Pubmed: 23869388]

METHODS AND RESULTS:
A new compound 3-acetyloxy-epicycloeucalenol-24-one (1), with 11 known compounds 3α-acetyloxy-4α,14α-dimethyl-9β,19-cycloergost-24-oic acid (2), 3-epicycloeucalenol (3), 3-epicycloeucalenyl-24-one (4), 3-epicycloeucalenyl acetate (5), 4β,14α-dimethyl-5α-ergosta-9β,19-cyclo-24(31)-en-3β-hydroxy-4α-carboxylic acid (6), cycloeucalenone (7), friedelin (8), Epifriedelanol (9), lup-20 (29)-en-3β,30-diol (10), betulin (11), lupeol (12), was isolated from the stems and leaves of Quercus variabilis Blume.
CONCLUSIONS:
Seven compounds (1-7) showed anti-inflammatory activity.