Dehydrodicentrine
Dehydrodicentrine showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 value of 2.98 μM.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Plant Direct.2021, 5(12):e372.
Int Immunopharmacol. 2020, 83:106403.
Anal Chim Acta.2018, 1039:162-171
J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
Cancers (Basel).2021, 13(6):1432.
Int J Mol Sci.2023, 24(4):3682.
Biosci Rep.2018, 38(4)
Plants (Basel).2022, 11(21):2947.
South African Journal of Botany2024, 168:209-220.
Food Chem X.2024, 21:101127.
Related and Featured Products
Fitoterapia. 2015 Jul;104:102-7.
Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea.[Pubmed:
26028544]
METHODS AND RESULTS:
An unusual proaporphine alkaloid bearing an isopropanenitrile group at isoquinoline nitrogen, named epiganine A (1) and a new aporphine alkaloid, epiganine B (2), together with eight known alkaloids, pronuciferine (3), Dehydrodicentrine (4), romerine (5), romeline (6), N-methylcalycinine (7), phanostenine (8), dicentrine (9), and N-methyllaurotetanine (10), were isolated from the roots of Stephania epigaea. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD) and comparing with experimental data.
CONCLUSIONS:
Compounds 2 and 4 showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 values of 4.36 and 2.98μM, respectively. Compounds 5-9 also exhibited potent AChE inhibitory activities.
