DL-alpha-Tocopherylacetate
Dl-alpha-tocopheryl acetate is a dietary supplement.
Dl-alpha-Tocopherylacetate shows anti-inflammatory and analgesic activity, it acts synergistically with aspirin towards reducing inflammation and pain as well as the former reduced the gastric ulcerogenic potential of the latter. Dl-alpha-Tocopherylacetate induces hypocoagulability and platelet hypoaggregability in rats.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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J Agric Food Chem. 2006 Jan 25;54(2):568-73.
Incorporation of alpha-tocopherol and linoleic acid in fresh lambs by feeding chemically treated dietary supplements containing dl-alpha-tocopheryl acetate and sunflower oil.[Pubmed:
16417322 ]
The effects of feeding chemically treated dietary supplements (CTDS) containing sunflower oil and dl-alpha-tocopheryl acetate (TA) on alpha-tocopherol content and fatty acid profile in edible tissues of lambs were estimated.
METHODS AND RESULTS:
Compared with lambs fed control diet (CD), lambs fed CD plus 250 IU of either TA or CTDS increased serum alpha-tocopherol. The CTDS-fed lambs further increased serum alpha-tocopherol by 29% over those fed CD plus 250 IU of TA. Lambs supplemented with TA or CTDS increased alpha-tocopherol in muscle and adipose tissues as compared with lambs fed CD. The CTDS-fed lambs had higher levels of alpha-tocopherol in gluteus medius (7.55 vs 6.05 mug/g), psoas major (7.43 vs 6.02 mug/g), and subcutaneous fat (12.6 vs 9.98 mug/g) compared with the TA-fed lambs.
CONCLUSIONS:
Feeding lambs CTDS also substantially increased levels of linoleic acid in the adipose tissues while decreasing the content of palmitic and oleic acids.
Int J Vitam Nutr Res. 1987;57(4):375-9.
dl-alpha-Tocopheryl acetate induces hypocoagulability and platelet hypoaggregability in rats.[Pubmed:
3440712]
METHODS AND RESULTS:
Rats receiving daily IP injections of DL-alpha-Tocopherylacetate (50 mg/kg) for 4 days showed levels of plasma alpha-tocopherol slightly increased and normal platelet count but platelet aggregation (induced by ADP or adrenaline) was significantly decreased when compared with the control animals. In addition, both platelet-rich plasma and platelet-poor plasma-thromboelastograms from treated rats showed thromboplastine-formation times significantly higher than those from control animals. Serum biochemical parameters showed several minor modifications in treated rats with respect the control ones.
CONCLUSIONS:
It suggests that vitamin E could be considered as a possible useful tool for the therapy of several hyperaggregable or hypercoagulable states.
International Journal of Drug Development & Research, 2011, 3(4):86-93.
Anti-Inflammatory and Analgesic activity of Dl-Alpha-Tocopheryl Acetate and its interaction with aspirin in Wistar rats.[Reference:
WebLink]
METHODS AND RESULTS:
In the present study anti inflammatory activity of different doses of DL-alpha-Tocopherylacetate viz., 9,18,36 and 72 mg/kg is investigated in both acute and sub-acute models of inflammation in rats. Similarly their analgesic activity and effect on gastric ulcer were also studied. The study also aimed to elicit the possible interactions of DL-alpha-Tocopherylacetate with aspirin. Except 9 mg/kg, all the therapeutic equivalent doses of DL-alpha-Tocopherylacetate in acute model and in the dose of 36 and 72 mg/kg in sub-acute model of inflammation exerted significant anti-inflammatory activity. Combination of sub anti-inflammatory (SAI) dose of DL-alpha-Tocopherylacetate (9mg/kg) with that of aspirin (54mg/kg) showed significant anti-inflammatory activity in both the models of inflammation. Dl-alpha-tocopheryl acetate in the dose of 18, 36 and 72 mg/kg individually and its SAI dose when coadministered with that of aspirin showed significant analgesic activity at 1 and 3 hours. DL-alpha-Tocopherylacetate in the dose of 36 and 72 mg/kg and combination treatment of SAI dose of dl-alpha-tocopheryl acetate with that of aspirin found to be gastroprotective.
CONCLUSIONS:
These findings clearly indicate the anti-inflammatory and analgesic activity of dl-alpha-tocopheryl acetate. In interaction studies, DL-alpha-Tocopherylacetate acts synergistically with aspirin towards reducing inflammation and pain as well as the former reduced the gastric ulcerogenic potential of the latter. If these findings are extrapolated to human beings, Vitamin E can be used individually or else as an adjuvant to NSAIDs in the treatment of inflammatory conditions. Clinical studies in this regard are really worthwhile.
