(-)-Curine
(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
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Biomed Pharmacother. 2017 May;89:894-901.
(-)-Curine induces cell cycle arrest and cell death in hepatocellular carcinoma cells in a p53-independent way.[Pubmed:
28292017 ]
Hepatocellular carcinoma(HCC) is one of the most common malignancies worldwide, however, drug resistance is still a tough problem of it.
METHODS AND RESULTS:
As in many other cancers, p53 mutations are commonly observed in HCCs (Hussain et al., 2007; Levine et al., 1994) [1,2]. Tumor tissues with mutant p53 seems to be more aggressive and resist to chemotherapy than that harboring wide-type p53 (Harris and Hollstein, 1994; Parrales and Iwakuma, 2015) [3,4]. (-)-Curine, a novel bisbenzylisoquinoline alkaloid, is one of the main components isolated from the roots of Cyclea wattii. Here, it was found to exert cytotoxity on hepatocellular carcinoma (HCC) cells regardless of p53 status. We found that (-)-Curine induced G1 arrest and cell death in HepG2 cells with wild-type p53 as well as Huh-7 cells with mutant p53. In HepG2 cells, knocking down of p53 did not change its cellular responses to (-)-Curine, and same degree of G1 arrest and cell death were occurred after p53 knockdown.
CONCLUSIONS:
Taken together, our data demonstrate that (-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status. It shed light on new therapy methods for HCC.
J Org Chem. 2017 Jan 20;82(2):1205-1217.
A Modular Access to (±)-Tubocurine and (±)-Curine - Formal Total Synthesis of Tubocurarine.[Pubmed:
27997804 ]
METHODS AND RESULTS:
Two consecutive Cu-catalyzed Ullmann-type C-O couplings permitted the first successful entry toward the curare alkaloids (+)-tubocurine, (-)-tubocurine, (+)-curine and (-)-Curine.
CONCLUSIONS:
Starting from vanillin, the synthetic sequence comprises 15 linear steps and includes a total of 24 transformations. In addition, the total synthesis of tubocurine represents a formal total synthesis of the famous arrow poison alkaloid tubocurarine.
