Cucurbitacin A

Cucurbitacin A
Product Name Cucurbitacin A
CAS No.: 6040-19-3
Catalog No.: CFN90324
Molecular Formula: C32H46O9
Molecular Weight: 574.71 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: ROCK
Source: The rhizomes of Hemsleya amabilis Diels.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Journal of Functional Foods2021, 84:104581
  • Plant Cell Tiss Org2017, 479-486
  • Int J Mol Sci.2022, 23(10):5468.
  • Int J Mol Sci.2022, 23(5):2796.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Agriculture2024, 14(12), 2301
  • J Nat Med.2017, 71(4):745-756
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • The Korea Journal of Herbology2016, 29-35
  • Molecules.2021, 26(9):2791.
  • Tetrahydroisocucurbitacin I

    Catalog No: CFN92892
    CAS No: 3877-89-2
    Price: Inquiry(manager@chemfaces.com)
    Cucurbitacin IIA

    Catalog No: CFN98171
    CAS No: 58546-34-2
    Price: $118/20mg
    Cucurbitacin Q1

    Catalog No: CFN91760
    CAS No: 99530-82-2
    Price: $318/10mg
    Cucurbitacin R

    Catalog No: CFN92895
    CAS No: 55903-92-9
    Price: Inquiry(manager@chemfaces.com)
    Dihydrocucurbitacin B

    Catalog No: CFN92140
    CAS No: 13201-14-4
    Price: $318/10mg
    Fabacein

    Catalog No: CFN91586
    CAS No: 37710-13-7
    Price: Inquiry(manager@chemfaces.com)
    Arvenin II

    Catalog No: CFN92896
    CAS No: 65247-28-1
    Price: Inquiry(manager@chemfaces.com)
    Arvenin III

    Catalog No: CFN95327
    CAS No: 65597-45-7
    Price: $318/5mg
    Hexanorcucurbitacin D

    Catalog No: CFN92893
    CAS No: 29065-05-2
    Price: Inquiry(manager@chemfaces.com)
    Cucurbitacin D

    Catalog No: CFN90209
    CAS No: 3877-86-9
    Price: $238/10mg
    Biochem. Pharmacol., 2015, 102:45-63.
    Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase.[Pubmed: 26707799 ]
    Cucurbitacins are cytotoxic triterpenoid sterols isolated from plants. One of their earliest cellular effect is the aggregation of actin associated with blockage of cell migration and division that eventually lead to apoptosis.
    METHODS AND RESULTS:
    We unravel here that cucurbitacin I actually induces the co-aggregation of actin with phospho-myosin II. This co-aggregation most probably results from the stimulation of the Rho/ROCK pathway and the direct inhibition of the LIMKinase. We further provide data that suggest that the formation of these co-aggregates is independent of a putative pro-oxidant status of cucurbitacin I.
    CONCLUSIONS:
    The results help to understand the impact of cucurbitacins on signal transduction and actin dynamics and open novel perspectives to use it as drug candidates for cancer research.
    Pilosidine

    Catalog No: CFN95110
    CAS No: 229971-57-7
    Price: $413/5mg
    1-Phenyl-2-propanol

    Catalog No: CFN95129
    CAS No: 14898-87-4
    Price: $30/20mg
    4-Hydroxybenzoyl choline

    Catalog No: CFN95158
    CAS No: 5094-31-5
    Price: $318/20mg
    (3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol

    Catalog No: CFN95227
    CAS No: 232261-31-3
    Price: $318/5mg
    Quasipanaxatriol

    Catalog No: CFN95248
    CAS No: 171903-78-9
    Price: $413/5mg
    Lathyranoic acid A

    Catalog No: CFN95325
    CAS No: 850560-44-0
    Price: $318/5mg
    New compound 9

    Catalog No: CFN95342
    CAS No: N/A
    Price: $413/5mg
    8-Hydroxypinoresinol-4'-O-beta-D-glucopyranoside

    Catalog No: CFN95356
    CAS No: 102582-69-4
    Price: $318/5mg
    Methyl lucidenate C

    Catalog No: CFN95541
    CAS No: N/A
    Price: $413/5mg
    Mahuannin G

    Catalog No: CFN95553
    CAS No: N/A
    Price: $318/5mg