Cimicifugic acid B
Cimicifugic acid B shows inhibitory collagenolytic activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Biological & pharmaceutical bulletin, 2002, 24(10):1198-201.
Effects of Fukinolic Acid and Cimicifugic Acids from Cimicifuga Species on Collagenolytic Activity.[Reference:
WebLink]
METHODS AND RESULTS:
The inhibitory collagenolytic activity (47-64% inhibition in 0.22-0.24 microM) of fukinolic acid and cimicifugic acid A, Cimicifugic acid B, and cimicifugic acid C, which are esters of fukiic acid (3',4'-dihydroxybenzyl tartaric acid) was more potent than that (20-37% inhibition in 0.23-0.24 microM) of cimicifugic acids D, E, F, which are esters of pscidic acid (4'-hydroxybenzyl tartaric acid). Since fukiic acid showed weaker inhibition, and caffeic acid, ferulic acid, isoferulic acid, and p-coumaric acid showed far weaker activities, the entire structures of fukinolic acid and cimicifugic acid A, Cimicifugic acid B, and cimicifugic acid C proved to be responsible for the inhibitory activities. Trypsin and pronase E hydrolyzed collagen nonselectively alone or in addition to collagenase. These collagenolytic activities were also inhibited by fukinolic acid. These results show that fukinolic acid may inhibit either the collagenolytic activities specific to collagenase or nonspecific to other emzymes.
CONCLUSIONS:
The present studies suggest the potential effect of fukinolic acid and cimicifugic acids of Cimicifuga rhizomes in preventing collagen degradation by collagenases or collagenolytic enzymes under pathological conditions, wound healing, or inflammation.
Chemical and Pharmaceutical Bulletin, 1988,46(2):362-365.
Three New Fukiic Acid Esters, Cimicifugic Acids A, B and C, from Cimicifuga Simplex WORMSK.[Reference:
WebLink]
METHODS AND RESULTS:
Three new fukiic acid esters, cimicifugic acid A (1), Cimicifugic acid B (2), and cimicifugic acid C (3), were isolated along with fukinolic acid (4), fukiic acid (5), caffeic acid (6), ferulic acid (7), isoferulic acid (8), 3, 4-dimethoxycinnamic acid (9) and p-coumaric acid (10) from Cimicifuga simplex.
CONCLUSIONS:
Their structures were identified as 2-feruloyl, 2-isoferuloyl, and 2-p-coumaroyl fukiic acid (1-3) on the basis of spectroscopic and chemical data.
