Calyxamine B
Calyxamine B has inhibitory activity on acetylcholinesterase, the effect is comparable to the natural inhibitors.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Cancers (Basel).2023, 15(1):37.
Food Bioscience2024, 58:103691.
Antioxidants (Basel).2023, 12(1):189.
Br J Pharmacol.2024, 181(24):5009-5027.
J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
Genes (Basel).2021, 12(7):1024.
ACS Omega.2024, 9(12):14356-14367.
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TCI CO.2019, US20190151281A1
Medicinal Chemistry Research 2021, 30:1117-1124.
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Tetrahedron Lett., 2013, 54 (50):6852-4.
Two-step synthesis and biological evaluation of calyxamines A and B[Reference:
WebLink]
METHODS AND RESULTS:
A two-step synthesis of naturally occurring alkaloids calyxamine A and Calyxamine B featuring a tandem Mannich–aldol condensation reaction under solvent free conditions, and their inhibitory activity against acetylcholinesterase (AChE) is reported.
J Nat Prod. 1997 Dec;60(12):1331-3.
Calyxamines A and B, novel piperidine alkaloids from the Caribbean sea sponge Calyx podatypa.[Pubmed:
9428165]
METHODS AND RESULTS:
Calyxamine A (1) and Calyxamine B (2) are 2,2,4,6,6-pentasubstituted piperidine alkaloids possessing novel carbon skeletons isolated from the marine sponge Calyx podatypa collected in Puerto Rico.
CONCLUSIONS:
Their structures, after derivatization with trifluoroacetic acid, have been determined by a combination of X-ray and spectroscopic methods. A plausible biogenetic pathway to the calyxamines is suggested.
