Buxbodine B
Buxbodine B has weak anti-AChE activity with IC50 values in the range of 10.8-98μM.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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The Catharanthus Genome2022,35-83.
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Nat Commun.2019, 10(1):2745
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Food Chem.2016, 191:81-90
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Steroids. 2015 Mar;95:73-9.
Bioactive steroidal alkaloids from Buxus macowanii Oliv.[Pubmed:
25528196]
METHODS AND RESULTS:
Chemical investigation of the crude methanolic extract of Buxus macowanii resulted in the isolation of five new steroidal alkaloids, 31-hydroxybuxatrienone (1), macowanioxazine (2), 16α-hydroxymacowanitriene (3), macowanitriene (4), macowamine (5), along with five known steroidal bases, Nb-demethylpapillotrienine (6), moenjodaramine (7), irehine (8), Buxbodine B (9) and buxmicrophylline C (10). Structures of compounds 1-10 were elucidated with the aid of spectroscopic methods including 1D and 2D NMR techniques and mass spectrometry. Compounds 1, 3, and 4 belong to a rare class of Buxus alkaloids having Δ(1,2) 9(10→19) abeo triene system.
CONCLUSIONS:
All isolates were evaluated for in vitro acetylcholinesterase (AChE) inhibitory activity and found to exhibit moderate to weak anti-AChE activity with IC50 values in the range of 10.8-98μM.
Compounds 1 and 6 were also moderately active in BACE1 inhibitory assay.
Acta Botanica Yunnanica, 2001,23(3):357-62.
Steroidal Alkaloids from Buxus bodinieri[Reference:
WebLink]
Five new steroidal alkaloids have been isolated from Buxus bodinieri Lévl.,a common ornamental in South-China.
METHODS AND RESULTS:
On the basis of IR, UV, MS, NMR spectral analyses and chemical evidence, the chemical structure of these new steroidal alkaloids were deduced as: buxbodine A (1)(20α- dimethylamino-9β,19-cyclo-4,4,14α-trimethy-5α-pregnane); Buxbodine B (2)(16β-hydroxy-20α-dimethylamino-9β,19-cyclo-4,4,14α-trimethy-5α-pregn-1(2)-en-3-one); buxbodine C (3)(3β-dimethylamino-9β,19-cyclo-4,4,14α-trimethy-5α-pregn-6(7), 17 (20)-dien-16-one), buxbodine D (4)(3β-dimethylamino-20α-acetoxylamino-9β,19-cyclo -4,4,14α-trimethy-5α-pregn-6(7)-ene) and buxbodine E (5)(3(-dimethylamino-20α-amino -9β,19-cyclo-4,4,14α-trimethy-5α-pregn-6(7)-ene), respectively.
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