Aflavazole
Aflavazole displays significant antifeedant activity against the fungivorous beetle Carpophilus hemipterus.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Organic Chemistry, 1990, 55(18):5299-5301.
Aflavazole: A new antiinsectan carbazole metabolite from the sclerotia of Aspergillus flavus.[Reference:
WebLink]
METHODS AND RESULTS:
The isolation, structure elucidation and biological activity of Aflavazole, a carbazole metabolite from the sclerotia of A. flavus, are reported.
CONCLUSIONS:
Aflavazole displayed significant antifeedant activity against the fungivorous beetle Carpophilus hemipterus when incorporated into a standard test diet at 100 p.p.m.
J Am Chem Soc. 2016 Dec 7;138(48):15555-15558.
Total Syntheses of Aflavazole and 14-Hydroxyaflavinine.[Pubmed:
27934032 ]
The first total syntheses of Aflavazole (6) and 14-hydroxyaflavinine (8), two sterically congested indole diterpenoids, were accomplished. AlI3-promoted alkyne Prins cyclization was exploited to construct their key structural motifs. An electrocyclization-aromatization sequence assembled the pentasubstituted arene of 6, and a Stille-Migita coupling furnished the tetrasubstituted olefin of 8. The benzylic and allylic C-O bonds were reductively cleaved at the late stage of the syntheses, respectively.
