6-Hydroxybenzofuran-2(3H)-one
Molecular docking studies of all compounds( thirteen novel 6-Hydroxybenzofuran-2(3H)-one(6-hydroxybenzofuran-3(2H)-one)) on the active sites of microbial enzymes indicated a possible target N-myristoyltransferase (NMT).
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Letters in Drug Design & Discovery, 2013,10(9):798-807.
Synthesis, Antimicrobial Activities and Molecular Docking Studies of Novel 6-Hydroxybenzofuran-3(2H)-one Based 2,4-Disubstituted 1,3-Thiazoles.[Reference:
WebLink]
METHODS AND RESULTS:
Synthesis, characterization and investigation of antibacterial and antifungal activities of thirteen novel 6-Hydroxybenzofuran-2(3H)-one(6-hydroxybenzofuran-3(2H)-one)
based 2,4-disubstituted 1,3-thiazoles are presented. Their structures were determined using NMR, FAB MS and HRMS analyses. The results of microbiological screening reveal that three derivatives containing fluorine, bromine and hydrogen substituents at the phenyl ring are the most active antimicrobial compounds.
CONCLUSIONS:
Molecular docking studies of all compounds on the active sites of microbial enzymes indicated a possible target N-myristoyltransferase (NMT).
