6-Hydroxybenzofuran-2(3H)-one
Molecular docking studies of all compounds( thirteen novel 6-Hydroxybenzofuran-2(3H)-one(6-hydroxybenzofuran-3(2H)-one)) on the active sites of microbial enzymes indicated a possible target N-myristoyltransferase (NMT).
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Letters in Drug Design & Discovery, 2013,10(9):798-807.
Synthesis, Antimicrobial Activities and Molecular Docking Studies of Novel 6-Hydroxybenzofuran-3(2H)-one Based 2,4-Disubstituted 1,3-Thiazoles.[Reference:
WebLink]
METHODS AND RESULTS:
Synthesis, characterization and investigation of antibacterial and antifungal activities of thirteen novel 6-Hydroxybenzofuran-2(3H)-one(6-hydroxybenzofuran-3(2H)-one)
based 2,4-disubstituted 1,3-thiazoles are presented. Their structures were determined using NMR, FAB MS and HRMS analyses. The results of microbiological screening reveal that three derivatives containing fluorine, bromine and hydrogen substituents at the phenyl ring are the most active antimicrobial compounds.
CONCLUSIONS:
Molecular docking studies of all compounds on the active sites of microbial enzymes indicated a possible target N-myristoyltransferase (NMT).
