5-Deoxystrigol
5-Deoxystrigol is a highly active Striga germination stimulant. It has a protective effect on D-galactosamine (D-GalN) induced mice acute liver injury and has a protective effect on CCl4 induced mice acute liver injury.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4471-4476.
Mutation in sorghum LOW GERMINATION STIMULANT 1 alters strigolactones and causes Striga resistance.[Pubmed:
28396420]
Striga is a major biotic constraint to sorghum production in semiarid tropical Africa and Asia. Genetic resistance to this parasitic weed is the most economically feasible control measure. Mutant alleles at the LGS1 (LOW GERMINATION STIMULANT 1) locus drastically reduce Striga germination stimulant activity.
METHODS AND RESULTS:
We provide evidence that the responsible gene at LGS1 codes for an enzyme annotated as a sulfotransferase and show that functional loss of this gene results in a change of the dominant strigolactone (SL) in root exudates from 5-Deoxystrigol, a highly active Striga germination stimulant, to orobanchol, an SL with opposite stereochemistry. Orobanchol, although not previously reported in sorghum, functions in the multiple SL roles required for normal growth and environmental responsiveness but does not stimulate germination of Striga.
CONCLUSIONS:
This work describes the identification of a gene regulating Striga resistance and the underlying protective chemistry resulting from mutation.
CN 105287502 A[P]. 2016.
Application of 5-deoxystrigol in preparation of medicines for preventing and treating liver injury[Reference:
WebLink]
METHODS AND RESULTS:
The inventor discloses 5-Deoxystrigol which has a protective effect on D-galactosamine (D-GalN) induced mice acute liver injury and has a protective effect on CCl4 induced mice acute liver injury.
CONCLUSIONS:
Thus, 5-Deoxystrigol can be used in preparation of medicines for preventing and treating liver injury or hepatitis and is disclosed for the first time.
As the skeleton type belongs to a brand-new skeleton type and 5-Deoxystrigol has strong therapeutic activity on liver injury, 5-Deoxystrigol has outstanding substantial characteristics and obviously has prominent progress when used in anti-liver injury.
