4-Aminobutanoic acid
Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age, suggests treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Foods.2022, 11(6):882.
Int Immunopharmacol.2021, 101(Pt A):108181.
Sci Rep.2018, 8:9267
Int Immunopharmacol.2023, 125:111175.
Molecules.2021, 26(9):2526.
Sci Rep.2016, 6:25094
Biomed Pharmacother.2022, 156:113929.
J Herbmed Pharmacol.2018, 7(4):280-286
iScience.2023, 26(9):107602.
Molecules.2023, 28(8):3291.
Related and Featured Products
Depress Anxiety. 2014 Oct;31(10):814-21.
Anxiety in major depression and cerebrospinal fluid free 4-Aminobutanoic acid.[Pubmed:
24865448]
Low 4-Aminobutanoic acid (GABA) is implicated in both anxiety and depression pathophysiology. They are often comorbid, but most clinical studies have not examined these relationships separately.
METHODS AND RESULTS:
We investigated the relationship of cerebrospinal fluid (CSF) free 4-Aminobutanoic acid to the anxiety and depression components of a major depressive episode (MDE) and to monoamine systems. Psychic anxiety severity increased with age and correlated with lower CSF free 4-Aminobutanoic acid, controlling for age. CSF free 4-Aminobutanoic acid declined with age but was not related to depression severity. Other monoamine metabolites correlated positively with CSF 4-Aminobutanoic acid but not with psychic anxiety or depression severity. CSF free 4-Aminobutanoic acid was lower in MDD compared with bipolar disorder and healthy volunteers. 4-Aminobutanoic acid levels did not differ based on a suicide attempt history in mood disorders. Recent exposure to benzodiazepines, but not alcohol or past alcoholism, was associated with a statistical trend for more severe anxiety and lower CSF 4-Aminobutanoic acid.
CONCLUSIONS:
Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age. This relationship is not seen with monoamine metabolites, suggesting treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.
Poult Sci. 2014 Oct;93(10):2490-500.
Effect of 4-Aminobutanoic acid on digestive enzymes, absorption function, and immune function of intestinal mucosa in heat-stressed chicken.[Pubmed:
25085934]
To explore the effect of dietary 4-Aminobutanoic acid (GABA) on digestive enzyme activity, absorption function and immune function of intestinal mucosa in heat-stressed Wenchang chicken were studied.
METHODS AND RESULTS:
One-day-old male Wenchang chickens were randomly divided into a control group (CK), heat stress group (HS), and 4-Aminobutanoic acid+HS group. The chickens from the 4-Aminobutanoic acid+HS group were administered with 0.2 mL of 4-Aminobutanoic acid solution daily. Chickens from HS and 4-Aminobutanoic acid+HS groups were subjected to heat stress treatment at 40 ± 0.5°C for 2 h during 1300 to 1500 h every day. Blood was drawn and 0.5 cm-long duodenum, jejunum, and ileum were collected from the chickens on d 3, 5, 7, 9, 12, and 15. Results showed that the activity of Ca²⁺-Mg²⁺-adenosine triphosphatase (ATPase), Na⁺-K⁺-ATPase, maltase, sucrase, and alkaline phosphatase, the contents of secretory IgA, glutathione, and d-xylose, and the number of lymphocytes in HS group were significantly lower than those in the CK group. Among them, some were rescued after the treatment of 4-Aminobutanoic acid as the time extension.
