3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid
3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid is a natural product from Uncaria sessilifructus.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
Biomed Pharmacother.2024, 176:116765.
Food Chem.2017, 228:301-314
Biofactors.2018, 44(2):168-179
Cell Mol Biol (Noisy-le-grand).2023, 69(15):167-173.
Faculty of Chem. & Nat. Resource Eng.2014, 62
J Sci Food Agric.2018, 98(3):1153-1161
Preprints2024, 2085.v1
Int J Mol Sci.2017, 18(5)
Front Pharmacol. 2024, 15:1527494.
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Magn Reson Chem. 2008 Jun;46(6):571-5.
Complete assignments of 1H and 13C NMR spectral data for three polyhydroxylated 12-ursen-type triterpenoids from Dischidia esquirolii.[Pubmed:
18324739 ]
METHODS AND RESULTS:
The complete assignments of all the (1)H and (13)C NMR signals of three polyhydroxylated 12-ursen-type triterpenes, 6beta,19alpha,22alpha-trihydroxyurs-12-en-3-oxo-28-oic acid (1), 3beta,6alpha,19alpha,23-tetrahydroxyurs-12-en-28- oic acid (3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid,2) and 3beta,6beta,19alpha,23-tetrahydroxyurs-12-en-28-oic acid (3), were carried out by means of homo- and hetero-nuclear two-dimensional NMR experiments.
CONCLUSIONS:
Compounds 1-3 were isolated from the aerial parts of Dischidia esquirolii. Of them, 1 and 2 were identified as new polyhydroxylated ursolic acid derivatives. Compound 2 is the C-6 hydroxyl epimer of 3, which was isolated first from Adina rubella, and its structure is revised in this paper.
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