3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid
Product Name 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid
CAS No.: 870456-88-5
Catalog No.: CFN97432
Molecular Formula: C30H44O4
Molecular Weight: 468.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Targets: MRCK
Source: The roots of Pseudolarix kaempferi
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:
3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid inhibits the MRCKα kinase with Kd50 of 3.0 uM, it also inhibits the MRCKβ kinase with Kd50 of 3.2 uM; the role of Kinases in cancer onset and progression has made kinases a target for the control of some cancers, suggests that it may possess anticancer activity.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Plant Sci.2021, 313:111069.
  • Neurotoxicology.2022, 91:218-227.
  • Molecules.2020, 25(23):5556.
  • Evid Based Complement Alternat Med.2021, 2021:5585692.
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • World J Mens Health.2019, 10.5534
  • Evid-Based Compl Alt2020, 7202519:13
  • Pharmaceutics.2022, 14(12):2765.
  • Mol Neurobiol.2022, 02873-9.
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Mangiferolic acid

    Catalog No: CFN97742
    CAS No: 4184-34-3
    Price: Inquiry(manager@chemfaces.com)
    Isomangiferolic acid

    Catalog No: CFN97896
    CAS No: 13878-92-7
    Price: Inquiry(manager@chemfaces.com)
    23-Hydroxymangiferonic acid

    Catalog No: CFN97779
    CAS No: 232266-08-9
    Price: Inquiry(manager@chemfaces.com)
    3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

    Catalog No: CFN97432
    CAS No: 870456-88-5
    Price: Inquiry(manager@chemfaces.com)
    27-Hydroxymangiferolic acid

    Catalog No: CFN97802
    CAS No: 17983-82-3
    Price: Inquiry(manager@chemfaces.com)
    27-Hydroxymangiferonic acid

    Catalog No: CFN97732
    CAS No: 5132-66-1
    Price: Inquiry(manager@chemfaces.com)
    Cancer Res., 2014, 74(19 ):1754-1754.
    Cycloartane anticancer activity[Reference: WebLink]
    New cancer diagnoses remain on the rise despite significant improvements in early detection and treatment. The role of Kinases in cancer onset and progression has made kinases a target for the control of some cancers. The MRCKα/β kinases have recently been implicated in cancer onset and progression and as such could serve as a potential drug target. The discovery that kinases are most effectively inhibited by small molecules has also resulted in an increased search for small molecule kinase inhibitors. Cycloartanes are small molecules found in many medicinal plants including the Jamaican Ball Moss (Tillandsia recurvata). Recent studies on T. recurvata have demonstrated that it possesses significant anticancer activity.Cycloartane-3,24,25-triol, an analog of a cycloartane identified in Ball moss was also shown to have inhibitory activity against MRCKα kinase.
    METHODS AND RESULTS:
    This study was as such set up to determine the MRCKα/β kinase inhibition activity of other cycloartanes in Ball Moss and their analogs. The kinase inhibitory activity of 6 cycloartanes was investigated using the ligand-kinase binding assay while the WST-1 reagent assay was used to determine the antiproliferative activity of the cycloartanes against some prostate and breast cancer cell lines. Cycloart-23-ene-3,25-diol (1), Cycloartane-3,24,25-triol (2), Cycloart-25-ene-3,24-diol (3), 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid (4), 24,25-Dihydroxycycloartan-3-one (5) inhibited the MRCKα kinase with Kd of 0.21 μM, 0.25μM, 0.36 μM, 3.0 μM, and 2.1 μM respectively. Hydroxycycloart-23-en-3-one,25, (6) showed no inhibition against the MRCKα kinase. Compounds 1, 3, 4, 5 inhibited the MRCKβ kinase with Kd of 4.7 μM, 1.10 μM, 3.2 μM, and 9.8 μM, respectively. Three of the six cycloartanes exhibited antiproliferation activity against two prostate and breast cancer cell lines each.
    CONCLUSIONS:
    In conclusion, cycloart-23-ene-3,25-diol (1) showed the most promising activity against the MRCKα/β kinase out of the 6 cycloartanes screened demonstrating an interesting structure activity relationship profile when compared with the other molecules. Cycloart-23-ene-3,25-diol (1) deserves further studies to determine its in vivo efficacy and safety.
    Momordicoside X

    Catalog No: CFN95170
    CAS No: 1333321-50-8
    Price: $368/5mg
    Polygalin J

    Catalog No: CFN95175
    CAS No: N/A
    Price: $318/5mg
    Sphenanlignan

    Catalog No: CFN95245
    CAS No: 866347-36-6
    Price: $318/5mg
    Diosmin Impurity 8

    Catalog No: CFN95309
    CAS No: 28719-21-3
    Price: $318/10mg
    Diosmin Impurity 5

    Catalog No: CFN95311
    CAS No: 122087-66-5
    Price: $318/10mg
    Batatasin V

    Catalog No: CFN95320
    CAS No: 65817-45-0
    Price: $318/5mg
    Oxytroflavoside E

    Catalog No: CFN95464
    CAS No: 1391144-84-5
    Price: $318/5mg
    Ganoderic acid Df

    Catalog No: CFN95514
    CAS No: 1352033-73-8
    Price: $318/5mg
    Ephedrannin D1

    Catalog No: CFN95547
    CAS No: 1592431-55-4
    Price: $318/5mg
    Symplocoside

    Catalog No: CFN95552
    CAS No: 76502-76-6
    Price: $318/5mg