20-Deoxyingenol

20-Deoxyingenol
Product Name 20-Deoxyingenol
CAS No.: 54706-99-9
Catalog No.: CFN92870
Molecular Formula: C20H28O4
Molecular Weight: 332.4 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The seeds of Euphorbia lathyris L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $138/20mg
Standard reference
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Earth Environ. Sci. 2021, 905:012080.
  • Biorxiv.2020, doi: 10.1101.
  • Biomed Pharmacother.2024, 176:116765.
  • Molecules.2019, 24(22):E4022
  • Mol Biol Rep.2024, 51(1):56.
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Research on Crops.2017, 18(2)
  • Chem Biodivers.2023, 20(12):e202301461.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • J Cancer.2019, 10(23):5843-5851
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    METHODS AND RESULTS:
    Four new ingenane-type diterpenes, 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-acetylingenol (1), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-Deoxyingenol (2), 3-O-(2E,4Z-decadienoyl)-20-Deoxyingenol (3), and 3-O-(2E,4E-decadienoyl)-20-Deoxyingenol (4), two new jatrophane-type diterpenes, kansuinins D (9) and E (10), and four known ingenane-type diterpenes were isolated from the root of Euphorbia kansui. Their structures were elucidated by spectroscopic and chemical analysis, and individual Xenopus cells at the blastular stage were cultured with the diterpenes to test for biological activity.
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    20-Deoxyingenol diterpenes 3 and 4 induced the greatest cell cleavage arrest (0.5 micro g/ml of each compound resulted in >75% cleavage arrest), but cell cleavage inhibitory activity became weak when C-16 had an acyl residue. In contrast, the jatrophane diterpene kansuinin D (9) showed no activity.
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    These results indicated that the hydroxylation at the C-13 aliphatic acid ester of substrate 2 can significantly reduce the cytotoxic activity.
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