2'-Hydroxy-5'-methoxyacetophenone
2'-Hydroxy-5'-methoxyacetophenone [LD50 =1.03 μg/cm(2)] shows acaricidal potentials against D. farinae.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Journal of Apicultural Research2021, 60(1)
J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
Appl Microbiol Biotechnol.2016, 100(9):3965-77
J Ethnopharmacol.2019, 236:31-41
Cancer Sci.2022, 113(4):1406-1416.
Toxins (Basel).2019, 11(10):E575
Int J Mol Sci.2022, 23(21):12816.
J Appl Toxicol.2024, jat.4615.
Biosci Biotechnol Biochem.2020, 84(3):621-632
Pharmacia2024, 71:1-9.
Related and Featured Products
J Agric Food Chem. 2013 Aug 7;61(31):7568-73.
Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals.[Pubmed:
23855621]
METHODS AND RESULTS:
On the basis of the LD50 values against D. farinae, 3'-methoxyacetophenone (0.41 μg/cm(2)) was 89.9 times more toxic than DEET (36.87 μg/cm(2)), followed by 4'-methoxyacetophenone (0.52 μg/cm(2)), 2'-methoxyacetophenone (0.75 μg/cm(2)), 2'-Hydroxy-5'-methoxyacetophenone (1.03 μg/cm(2)), 2'-hydroxy-4'-methoxyacetophenone (1.29 μg/cm(2)), acetophenone (1.48 μg/cm(2)), 2'-hydroxyacetophenone (1.74 μg/cm(2)), 2',5'-dimethoxyacetophenone (1.87 μg/cm(2)), 2',4'-dimethoxyacetophenone (2.10 μg/cm(2)), and benzyl benzoate (9.92 μg/cm(2)). In regard to structure-activity relationships between acaricidal activity and functional radicals (hydroxyl and methoxy groups) on the acetophenone skeleton, a monomethoxy group (2'-, 3'-, and 4'-methoxyacetone) on the acetophenone skeleton was more toxic than were the other groups (2',4'- and 2',5'-dimethoxyacetophenone, 2'- and 4'-hydroxyacetophenone, 2'-hydroxy-4'-methoxyacetophenone, 2'-Hydroxy-5'-methoxyacetophenone, and 4'-hydroxy-3'-methoxyacetophenone).
CONCLUSIONS:
These results indicated that acaricidal activity against three mite species changed with the introduction of functional radicals (hydroxyl and methoxy groups) onto the acetophenone skeleton.
