Vasorelaxation

Norathyriol
Catalog No: CFN98468

Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. Norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer. Norathyriol may be a dual, yet weak, cyclooxygenase and lipoxygenase pathway blocker, it has anti-inflammatory effect, and has inhibitory effect on the A23187-induced pleurisy and acetic acid-induced writhing response in mice. Norathyriol can relax the rat thoracic aorta mainly by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated calcium channels. Norathyriol also can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK.

Alpinetin
Catalog No: CFN98489

Alpinetin has antibacterial, anti-inflammatory, and anti-cancer activities; it inhibits proliferation ,regulates of the Bcl-2 family and XIAP expression, releases of cytochrome c and activates caspases.

8(14),15-Isopimaradien-3-ol
Catalog No: CFN98708

ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. It displays high antibacterial activities (MIC values lower than 10 microg /mL for most pathogens).

Brazilin
Catalog No: CFN98711

Brazilin exhibits cancer preventive, anti-hepatotoxicity, antiplatelet activity, and anti-inflammatory activities, it also inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing of NF-κB activation in human dermal fibroblasts, thus, it might be used as a potential agent for treatment of UV-induced skin photoaging. Brazilin has anti-IKK activity, can selectively disrupt proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. Brazilin induces vasorelaxation by the increasing intracellular Ca(2+) concentration in endothelial cells of blood vessels and hence activating Ca(2+)/calmodulin-dependent NO synthesis.

Acetylcholine chloride
Catalog No: CFN90038

Acetylcholine Chloride is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine chloride in micromolar concentrations significantly inhibit p53 mutant peptide aggregation in vitro, and could be promising candidate for p53 mutant/ misfolded protein aggregation inhibition, and mutations of tumor suppressor protein p53 are present in almost about 50% of all cancers.