Pro-apoptotic

Angelicin
Catalog No: CFN98854

Angelicin has anti-cancer, antiviral, and anti-inflammatory activities; it regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. Angelicin is a powerful inducer of erythroid differentiation and -globin mRNA accumulation of human leukemia K562 cells, it is a potential therapeutic approach in hematological disorders, including -beta-thalassemia and sickle cell anemia.

Tryptophol
Catalog No: CFN98866

Tryptophol is an aromatic alcohol found as a secondary product of alcoholic fermentation that induces sleep in humans. Tryptophol can inhibit the infection/replication of GVE2 by interacting with the host's Clp protease. Tryptophol can inhibit the proliferation of U937 cells by inducing apoptosis via a pathway involving caspase-8 followed by caspase-3. Tryptophol induces apoptosis through Death Receptor (DR) 5 and that the resistance of peripheral blood lymphocytes (PBL) to tryptophol-induced apoptosis might be due to competition from decoy receptor (DcR).

Lactacystin
Catalog No: CFN00121

Lactacystin is a selective UPS inhibitor recently used to destroy dopamine (DA) neurons in animal models of Parkinson's disease (PD); marked differences in the rotational response to apomorphine and l-DOPA suggest different mechanisms of neurodegeneration evoked by Lactacystin and 6-OHDA. Lactacystin induces cell death and α-synuclein-positive inclusions in cytoplasm, it has diversified killing effects on gastric cancer cells, the mechanism may be related to induce the apoptosis by downregulation of nuclear factor kappa B viability.

Erythrodiol
Catalog No: CFN98914

Erythrodiol is the precursor of pentacyclic triterpenic acids, it exerts antiproliferative and proapoptotic activity in colon adenocarcinoma cells. Erythrodiol may have interesting therapeutic potential as new vasodilator drugs, thus protecting the cardiovascular system.

Pramanicin
Catalog No: CFN00133

Pramanicin, an antimicrobial agent, has vasorelaxant effect, it induces a slow endothelium-dependent relaxation, which could be reversed with the NO synthase inhibitor, L-NOARG, it has potent, selective, and irreversible inhibitory effect on the endothelial.Pramanicin as a potential apoptosis-inducing small molecule, which acts through a well-defined JNK- and p38-dependent apoptosis signalling pathway in Jurkat T leukemia cells.