Pro-apoptotic

beta-Eudesmol
Catalog No: CFN99537

Beta-eudesmol has potential anti-angiogenic and anti-tumour activities, it inhibits angiogenesis by suppressing CREB activation in growth factor signalling pathway, is an inhibitor of tumour growth. Beta-eudesmol induces neurite outgrowth in rat pheochromocytoma cells accompanied by an activation of mitogen-activated protein kinase, it may be a promising lead compound for potentiating neuronal function, and the drug may be useful in helping to clarify the mechanisms underlying neuronal differentiation.

Pachymic acid
Catalog No: CFN99590

Pachymic acid has sedative-hypnotic, cardioprotective,antioxidant, and anti-inflammatory activities, it has hypoglycemic activity ,can stimulate glucose uptake, GLUT4 gene expression and translocation, and promoting triglyceride accumulation in adipocytes. Pachymic acid may inhibit proliferation and invasion of ovarian carcinoma cell through decreasing β-catenin and COX-2 expression and increasing E-cadherin exprssion. Pachymic acid is suggested to prevent the complications of oral diseases such as inflammation and alveolar destruction of the oral cavity.

Palmitic acid
Catalog No: CFN99716

Palmitic acid induces anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism, it induces down-regulation of APOM expression, is mediated via the PPARβ/δ pathway. Palmitic acid induces degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes. it also shows in vivo antitumor activity in mice. Palmitic acid is CNS mediated via PKC-theta activation, resulting in reduced insulin activity.

Cyanidin-3-O-glucoside chloride
Catalog No: CFN99740

Cyanidin-3- O -glucoside exhibits strong antioxidant activities, it has protective effects from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Cyanidin-3-O-glucoside chloride decreased mutant p21 expression, and increased the ratio of Bax/Bcl-2 and the activation of caspase-3 to induce apoptosis. It has the function of raising blood sugar
concentration, maintaining the balance of Lipid metabolism and reducing obesity.

(20S)-Protopanaxdiol
Catalog No: CFN99764

20(S)-Protopanaxdiol may be a potential new P-gp inhibitor for cancer treatment, it may induce the apoptosis via the down-regulation of Bcl-2 protein and the up-regulation of γH2Ax protein expression; it may inhibit the proliferation of Siha cells via the up-regulating the expressions of p53, p21, and autophagy related gene Beclin 1and MAP1-LC3, and down-regulating the expression of cyclin-E.