Inhibitors

Norcantharidin
Catalog No: CFN99791

Norcantharidin has been used to treat human cancers in China since 1984, it inhibits the canonical Wnt signal pathway in NSCLC, by activating WIF-1 via promoter demethylation; it also enhances TIMP‑2 antitumor and anti‑vasculogenic mimicry activities in GBCs through downregulating MMP‑2 and MT1‑MMP. Norcantharidin is a protein phosphatase type-2A inhibitor, which has less nephrotoxic and phlogogenic side-effects, it can inhibit both DNA synthesis and granulocyte-macrophage colony-forming cells (GM-CFC)growth and impaire the neogenesis of chromatin material and nuclear membrane during the M/G1 phase transition in K-562 cells.

Phytic acid
Catalog No: CFN99792

Phytic acid is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It can act as a cofactor in DNA repair by nonhomologous end-joining. It is a trypsin inhibitor, has chelating, antioxidant, anti-inflammatory, and neuroprotective effects, it forms an iron chelate which greatly accelerates Fe2+-mediated oxygen reduction yet blocks iron-driven hydroxyl radical generation and suppresses lipid peroxidation. High concentrations of phytic acid prevent browning and putrefaction of various fruits and vegetables by inhibiting polyphenol oxidase, it may be a substitute for presently employed preservatives.

Hardwickiic acid
Catalog No: CFN99836

Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic acid shows antimicrobial activity, it can inhibit the growth of all the tested microbial species. (-)-Hardwickiic acid has insecticidal activity.

Oleoside
Catalog No: CFN99838

Oleacein is a strong Angiotensin Converting Enzyme (ACE)-inhibitor (IC50 = 26 uM).

4,5-Dimethoxycanthin-6-one
Catalog No: CFN99847

4,5-Dimethoxycanthin-6-one has antibacterial actiyity, it exhibits inhibition against Staphylococcus aureus and its drug-resistant strains. 4,5-Dimethoxycanthin-6-one has a strong inhibitory effect on cyclic adenosine monophosphate (cAMP) phosphodiesterase. It also shows cytotoxicity against the tumor cell lines, U937 and HepG2.