Antihypertensive

Acteoside
Catalog No: CFN97048

Acteoside is a lipase inhibitor, has neuroprotective, anti-obesity,anti-inflammatory, antioxidant, anticancer, cytotoxic,antihypertensive, analgesic, and antimetastatic activities. Acteoside can promote nerve growth factor and tropomycin receptor kinase A expression, inhibit arachidonic acid release and prostaglandin E2 production induced by 0.5 microM melittin. Acteoside can protect the cells from X‑ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl-2 ratio and downregulating the activity of procaspase-3, as well as modulating the mitogen‑activated protein kinase signaling pathways.

Gomisin J
Catalog No: CFN90124

Gomisin J is a good substrate of cytochrome P450 3A4(CYP3A4), it has vasodilatory, anti-inflammatory, anti-diabetes, anti-oxidant, and anti-cancer effects, it also has preventive effects on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Gomisin J has potential benefits in treating nonalcoholic fatty liver disease, it can suppress lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecule. Halogenated gomisin J is a potent inhibitor of the cytopathic effects of human immunodeficiency virus type 1 (HIV-1) on MT-4 human T cells (50% effective dose, 0.1 to 0.5 microM).

Saponarin
Catalog No: CFN90134

Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage. Saponarin exerts anti-inflammatory effects in LPS-induced RAW 264.7 macrophages via inhibition of NF-κB, ERK and p38 signaling.Saponarin is characterized as α-glucosidase inhibitor present in Tinospora cordifolia, it also has hypoglycemic activity in the range of 20-80 mg/kg compared to 100-200 mg/kg for acarbose as reported.Saponarin also exerts slight antihypertensive activity in non-diabetic spontaneously hypertensive rats (SHR).

3-Acetoxy-8(17),13E-labdadien-15-oic acid
Catalog No: CFN97090

ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation of the endothelial NO-cGMP pathway, the opening of K+ channels and the alteration on Ca2+ mobilization.

N-trans-Feruloyltyramine
Catalog No: CFN97135

N-trans-Feruloyltyramine(NTF) is a platelet aggregation inhibitor, which has hepatoprotective, and antioxidative effects, NTF is likely to inhibit COX enzymes, thereby suppressing P-selectin expression on platelets;NTF inhibits melanogenesis in a dose-dependent manner.