Antihypertensive

Cineole
Catalog No: CFN90545

Cineole has antihypertensive,and anti-inflammatory effects, it regulates nitric oxide and oxidative stress in rats chronically exposed to nicotine. Cineole can attenuate cerulein-induced AP via an anti-inflammatory mechanism and by combating oxidative stress, may can treat neurodegenerative disease.

Tilianin
Catalog No: CFN92764

Tilianin has anti-inflammatory, antiatherogenic, antihypertensive and vasorelaxant activities, mediates relaxation and antihypertension mainly by an endothelium-dependent manner, probably due to NO release, and also through an endothelium-independent pathway by opening K+ channels. Tilianin inhibits the tumor necrotic factor-K (TNF-K)-induced expression of VCAM-1 by 74% and reduces TNF-K-induced activation of nuclear factor-UB in cultured human umbilical vein endothelial cells (HUVECs).

Isorhamnetin 3-glucuronide
Catalog No: CFN90568

Isorhamnetin 3 -O -glucuronide exerts anti-inflammatory activity by increasing heme oxygenase-1 (HO-1) expression and by suppressing Jun N-terminal kinase (JNK) and p38 signaling pathways in LPS-challenged RAW264.7 macrophage cells. Isorhamnetin 3-glucuronide can inhibit vascular cell adhesion molecule-1 (VCAM-1) cell surface expression at 2 micromol/L, indicates that it can inhibit the expression of key molecules involved in monocyte recruitment during the early stages of atherosclerosis at physiological concentrations. It (1 mg/kg i.v.) can progressively reduce mean blood pressure (MBP), measured in conscious spontaneously hypertensive rats (SHR).

Hirsutine
Catalog No: CFN90617

Hirsutine has anticancer, cardioprotective, anti‑hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels. Hirsutine reduces the production of various neurotoxic factors in activated microglial cells and possesses neuroprotective activity in a model of inflammation-induced neurotoxicity.

Pseudoginsenoside RT1
Catalog No: CFN90656

Pseudoginsenoside RT1 can cause a decrease in blood pressure, an increase in heart rate and an increase in spontaneous contractility of the uterus.