Anticancer

Indicine
Catalog No: CFN00283

Indicine N-oxide is a more active antitumor agent than its free base Indicine.

Indicine N-oxide
Catalog No: CFN00284

Indicine N-oxide, a pyrrolizidine alkaloid present in the plant Heliotropium indicum, shows promising cytotoxic activity in various tumor models that due to its DNA damaging effects and depolymerization of microtubules.

Odorine
Catalog No: CFN97210

Odorine has potent anti-carcinogenic effect by inhibiting both the initiation and promotion stages of two-stage skin carcinogenesis. It was found to inhibit the growth of the vinblastine-resistant KB cells by enhancing the anticancer activity of vinblastine.

2,3-Dehydrokievitone
Catalog No: CFN97223

2,3- Dehydrokievitone exhibits strong cytotoxic activity and induces apoptosis efficiently in cancer cells.

Obacunone
Catalog No: CFN97233

Obacunone is a novel activator of Nrf2, which exhibits anti-cancer, anti-inflammatory, antivirulence, insecticidal, anti-proliferative and anti-aromatase activities. Obacunone stimulates muscle hypertrophy and prevents obesity and hyperglycemia, and that these beneficial effects are likely to be mediated through the activation of TGR5 and inhibition of PPARγ transcriptional activity. Obacunone significantly inhibits aromatase activity in an in vitro enzyme assay with an IC50 value of 28.04 μM, and it also inhibits the p38 MAPK signaling pathway.