Anticancer

Hydroxygenkwanin
Catalog No: CFN98021

Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin and Hydroxygenkwanin may be a promising method for glioma chemotherapy.

Daphnetin
Catalog No: CFN99952

Daphnetin is a dihydroxycoumarin that is being used in China for the treatment of coagulation disorders, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit antimalarial, anti-rheumatoid arthritis, anti-proliferative, anti-inflammatory and anti-oxidant activities. it is also a chelator and an antioxidant. Daphnetin can enhance immunological functions of B lymphocytes, the expression of IL-12 in B lymphocytes can be up-regulated by daphnetin through natural immunity approach.

Polyphyllin VI
Catalog No: CFN99954

Polyphyllin VI and polyphyllin VII possess anti-cancer activities, they exhibits strong inhibitory effects on lung cancer cell growth in vitro and in vivo by inducing G2/M cell cycle arrest and triggering apoptosis.

Polyphyllin G
Catalog No: CFN99955

Polyphyllin G has been shown to have strong anticancer activities in a wide variety of human cancer cell lines, it also shows significant anthelmintic activity against Dactylogyrus intermedius with EC50 values of 1.2 mg L(-1) and the acute toxicities (LC50) values of 2.9 mg L(-1).

Carnosol
Catalog No: CFN99956

Carnosol, a novel agonist of TRPA1 with an EC50 value of 12.46 uM, which exhibits anti-inflammatory, anti-nociceptive, hepatoprotective, antioxidant, anticarcinogen, anti-angiogenic, anti- invasive and antimetastatic properties. Carnosol can cause a significant decrease in both bacterial and yeast growth whilst, it may prove useful as a food antioxidant which could also contribute to the retardation of the microbial spoilage of foods; it also can inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism, it may be a potential drug against obesity-related diseases.