Anticancer

Embelin
Catalog No: CFN90537

Embelin is an inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay.Embelin has antitumor, antioxidant and anti-inflammatory activities. Embelin can enhance TRAIL-induced cell apoptosis through DR4 and DR5 upregulation and decrease IL-6-induced STAT3 phosphorylation, that combination of low-toxicity Embelin and TRAIL may become as a potential antileukemia strategy.

Humulone
Catalog No: CFN90541

Humulone, a bone resorption inhibitor, induces apoptosis may via its antioxidative activity in the premyocytic leukemia cell line HL-60 between 1 and 100 micrograms/ml. Humulone is also a potent angiogenic inhibitor, can inhibit cyclooxygenase-2 and may be a novel powerful tool for the therapy of various angiogenic diseases involving solid tumor growth and metastasis. Humulone also has antioxidant, antispasmodic, antiviral and antibacterial activities.

Isosteviol
Catalog No: CFN90544

Isosteviol possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, neuroprotective, antibacterial, antifungal,and antioxidant effects.Isosteviol plays a protective role in a variety of stress-induced cardiac diseases, it can prevent the prolongation of action potential in hypertrophied cardiomyoctyes by regulating transient outward potassium and L-type calcium channels.

RA-V
Catalog No: CFN92605

RA-V is an potential anti-angiogenic agent, exhibits anti-angiogenic activities in HUVEC and HMEC-1 cell lines with changes in function of these endothelial cells. RA-V also has anti-cancer activity, is a potential anti-metastatic agent in breast cancer, and likely acts via PI3K/AKT and NF-κB signaling pathways in both ER-positive and ER-negative breast cancer cells.

RA-XI
Catalog No: CFN92606

RA-XI shows potent antitumor activity against P-388.