Antiarrhythmic

Lappaconitine Hydrobromide
Catalog No: CFN90361

Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias, it is a selective blocker of the TTX-sensitive Na+ channels, and does not influence on the activation threshold of Na+ channels. Lappaconitine hydrobromide can be used for local anesthesia, and analgesic treatment. Lappaconitine hydrobromide has anti-inflammatory effects, it can remove inflammation and swelling, lower temperature and relieve heat.

Dihydroberberine
Catalog No: CFN90431

Dihydroberberine has anti-tumor activity. It also improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment.

L-Stepholidine
Catalog No: CFN90457

L-Stepholidine, which has dual actions on dopamine D1 and D2 receptors, attenuates heroin self-administration and cue-induced reinstatement. It also elicits anti-dyskinesia effects.

Dicentrine
Catalog No: CFN92331

Dicentrine, a selective α(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain. Dicentrine induces DNA lesions to arrest cell cycle. Callus and cell suspension cultures of S. venosa can produce high levels of Dicentrine as an alternative source of plant materials.

Daurisoline
Catalog No: CFN90534

Daurisoline is a hERG inhibitor and also an autophagy blocker.Daurisoline has antiarrhythmic effects, it( at concentrations below 30 uM) exerts a blocking effect on hERG, but does not affect the expression and function of the hERG channel, it also can inhibit early afterdepolarizations (EADs) which may be associated with its blockade effects on I(Ca-L). Daurisoline and its isomers show cytoprotective effects on ischemic injury in cultured pheochromocytoma (PC12) cells, which are mediated by blocking Ca2+ influx into cells.