Voleneol
1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2),suggest thats DE may be a good candidate to regulate LPS-induced inflammatory response.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Korean Journal of Pharmacognosy, 2015, 46(1): 12-6.
Anti-inflammatory effects of 1β‚6α-dihydroxyeudesm-4(15)-ene isolated from Myrrh on LPS-induced neuroinflammation in BV2 cells[Reference:
WebLink]
Myrrh is a resinous substance obtained from Commiphora trees, which has long been used as an antiseptic agent.A sesquiterpene, 1β, 6α-dihydroxyeudesm-4(15)-ene (DE,Voleneol), was isolated from the hot water extract of Myrrh.
METHODS AND RESULTS:
In the presentstudy, we found that DE attenuates the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells. DE significantlyinhibited LPS-induced production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin E2(PGE2) in BV2 microglia in a concentration-dependent manner without cytotoxic effect. Furthermore, DE dose-dependentlysuppressed the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
CONCLUSIONS:
These results suggest that DE may be a good candidate to regulate LPS-induced inflammatory response.
Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(24):2604-6.
Chemical constituents from aerial part of Curcuma wenyujin.[Pubmed:
18338597]
To investigate the chemical constituents from aerial part of Curcuma wenyujin.
METHODS AND RESULTS:
Compounds were isolated by repeated column chromatography on silica gel. Their structures were elucidated on the basis of spectral analysis and comparison with literature data. Six compounds were isolated and identified as codonolactone (1), Voleneol (2), octacosanoic acid (3), beta-sitosterol (4), mangdesisterol (5), and daucosterol (6).
CONCLUSIONS:
Compounds 1, 2, and 5 were isolated from the plant for the first time.
