Voleneol

Korean Journal of Pharmacognosy, 2015, 46(1): 12-6.

Anti-inflammatory effects of 1β‚6α-dihydroxyeudesm-4(15)-ene isolated from Myrrh on LPS-induced neuroinflammation in BV2 cells[Reference: WebLink]

Myrrh is a resinous substance obtained from Commiphora trees, which has long been used as an antiseptic agent.A sesquiterpene, 1β, 6α-dihydroxyeudesm-4(15)-ene (DE,Voleneol), was isolated from the hot water extract of Myrrh.
METHODS AND RESULTS:
In the presentstudy, we found that DE attenuates the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells. DE significantlyinhibited LPS-induced production of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin E2(PGE2) in BV2 microglia in a concentration-dependent manner without cytotoxic effect. Furthermore, DE dose-dependentlysuppressed the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
CONCLUSIONS:
These results suggest that DE may be a good candidate to regulate LPS-induced inflammatory response.

Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(24):2604-6.

Chemical constituents from aerial part of Curcuma wenyujin.[Pubmed: 18338597]

To investigate the chemical constituents from aerial part of Curcuma wenyujin.
METHODS AND RESULTS:
Compounds were isolated by repeated column chromatography on silica gel. Their structures were elucidated on the basis of spectral analysis and comparison with literature data. Six compounds were isolated and identified as codonolactone (1), Voleneol (2), octacosanoic acid (3), beta-sitosterol (4), mangdesisterol (5), and daucosterol (6).
CONCLUSIONS:
Compounds 1, 2, and 5 were isolated from the plant for the first time.