Ursolic aldehyde
Ursolic aldehyde can inhibit phosphatase of regenerating liver-3, with the IC(50) value of 50 +/- 0.3 mu M.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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University of Limpopo2016, 1777
Indian J Pharm Sci.2022, 84(3):144-151
Molecules.2017, 22(11)
Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
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Journal of the Korean Society for Applied Biological Chemistry, 2010, 53(1):97-100.
Triterpenoid and lignan from the fruits of Cornus kousa inhibit the activities of PRL-3 and LDL-Oxidation[Reference:
WebLink]
METHODS AND RESULTS:
Ursolic aldehyde (1) and (+)-lariciresinol (2) were isolated from the MeOH extracted fraction of the fruits of Cornus kousa by repeated column chromatographies.
CONCLUSIONS:
The structure of the compounds were determined by spectroscopic data including nuclear magnetic resonance spectrometry, mass spectrometry and infrared spectrometry Ursolic aldehyde inhibited phosphatase of regenerating liver-3 with IC 50 value of 50±0.3 μM. And (+)-lariciresinol inhibited low-density lipoprotein oxidation with an IC 50 value of 11.9±0.5 μM.
Natural Medicines, 2000, 54(6):297-305.
Acyl-CoA : Cholesterol Acyltransferase(ACAT) Inhibitors from Ilex spp.[Reference:
WebLink]
METHODS AND RESULTS:
Activity-guided fractionation of a methanol extract of the leaves ofIlex kudincha, I. latifolia and I. cornuta led to the isolation of twenty-six acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory triterpenes. Nineteen of them were identified by spectroscopic methods as uvaol (1), Ursolic aldehyde (2), ursolic acid (3), ursolic acid acetate (4), 23-hydroxyursolic acid (5), 2α-hydroxyuvaol (6), 11-oxoursolic acid (8), ilekudinol B methyl ester (10), 11,12-dehydroursolic acid lactone (11), ilekudinol A (13), ulmoidol (14), 27-trans-pcoumaroyloxyursolic acid (15), 3β-hydroxyolean-12-en-11-one (17), erythrodiol (18), oleanolic aldehyde (19), lupeol (21), betulin (22), ilekudinol C (23) and 30-oxolupeol (26), and seven were new compounds named ilelatifol A (7),ilecornol A methyl ester (9), ilelatifol D (12), ilelatifol C (16), ilelatifol B (20), ilekudinol D methyl ester (24) and ilekudinol E methyl ester (25).
CONCLUSIONS:
Compounds 4-7, 9-20 and 22-25 showed inhibitory activity in the ACAT assay.
