Rehmannic acid
Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Biochemical Pharmacology.1968 Jun;17(6):1079–1089.
Inhibition of biliary secretion by icterogenin and related triterpenes-I. Effect of icterogenin, rehmannic acid and oleanolic acetate on liver mitochondria in vitro.[Reference:
WebLink]
The effect of Icterogenin, Rehmannic acid and oleanolic acetate on respiration, mitochondrial structure and oxidative phosphorylation in rabbit and rat liver mitochondria was studied.
METHODS AND RESULTS:
All three substances at a concentration 1 × 1o−4 M and 5 × 10−5M inhibit the respiration of NAD-linked enzymes. Only Icterogenin in the concentration 1 × 10−5 M increased the respiration rate. The succinoxidase activity was inhibited by Rehmannic acid and oleanolic acetate. Icterogenin at the concentrations 1 × 10−4 M and 5 × 10−5 M did not cause any definite changes in respiration with succinate as substrate, but at the concentration 1 × 10-5 M the respiration was always increased.The substances were found to increase the mitochondrial membrane permeability and Icterogenin had a swelling effect of the large amplitude type. The oxidative phosphorylation was uncoupled by Icterogenin and Rehmannic acid and inhibited by oleanolic acetate. Rehmannic acid at a concentration 5 × 10−5 M almost completely abolished the phosphate uptake when glutamate was used as substrate. The effect of Icterogenin was less.
The respiration with glutamate as substrate was inhibited 50 per cent by the former and to about 25 per cent by the latter.
CONCLUSIONS:
With succinate as substrate, both Rehmannic acid and Icterogenin were potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter. The connection between chemical structure and effect on oxidative phosphorylation is discussed.
