Product Name Quercetin-3-O-glucuronide
CAS No.: 22688-79-5
Catalog No.: CFN92172
Molecular Formula: C21H18O13
Molecular Weight: 478.4 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Yellow powder
Targets: ROS | JNK | MAPK | C/EBPβ | IRS-1
Source: The vines of Vitis vinifera
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price: $198/10mg
Quercetin-3-O-glucuronide is a potent stilbene oxidase inhibitor, it has antioxidant, anti-atherogenic, and anti-inflammatory activities. Quercetin-3-O-glucuronide significantly improves Alzheimer's disease (AD)-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation, possibly through mechanisms involving the activation of the c-Jun N-terminal kinases and the mitogen-activated protein kinase signaling pathways. Quercetin-3-O-glucuronide is equally effective in inhibiting ROS-associated inflammation and ameliorating insulin resistant endothelial dysfunction by beneficial regulation of IRS-1 function.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • J Food Biochem.2019, 43(9):e12970
  • Int J Mol Sci.2019, 20(3):E651
  • Molecules.2017, 22(6)
  • Int J Mol Sci.2019, 20(11):E2734
  • BMC Complement Altern Med.2016, 16:213
  • Front Immunol.2018, 9:2655
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Int J Mol Sci.2019, 20(14):E3538
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • SBRAS2016, 12
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