Momordicoside A
Momordicoside A has the inhibition effect on PIP1B.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Journal of Shaanxi Normal University,2008 ,36 (4) :63-67.
Isolation of the saponins from Momordica charantia and their PTP1B inhibition activity.[Reference:
WebLink]
Five compounds were isolated from Momordica charantia L through the absorption of macroporous resin,silica gel column chromatography,reversed-phase silica gel column chromatography and detection of thin-layer chromatography(TLC).
METHODS AND RESULTS:
The structures of the compounds were characterized through the spectral technology including ESI-MS and NMR.They are α-spinasterol-3-Oβ-D-glucopyranoside(A),19(R)-carbonyl-25-dimethoxy-5β-5,19-epoxycucrbita-6,23-dien-3β-ol-3-Oβ-D-glucopyranoside(B),Momordicoside A(C),momordicoside L(D),and momordicoside K(E),respectively.The hypoglycemic activities of these five compounds were tested by using PTP1B(protein tyrosine phosphatase).
CONCLUSIONS:
The results indicated that the compounds D and E have not inhibition effect on PIP1B but the compound A,B and C have the inhibition effect.The sequence of inhibition activities is ACB.
Zhong Yao Cai. 1998 Sep;21(9):458-9.
Study on chemical components of Momordica charantia.[Pubmed:
12569838]
METHODS AND RESULTS:
The paper deals with the study of chemical constituents of the unmatured fruits of Chinese traditional medicine Momordica charantia L. which is usually used as green-stuff. There are two parts of the extracts obtained by ethanol precipitation, and four compounds obtained from the further isolation.
CONCLUSIONS:
They are identified as Vincine, Mycose, Momordicoside A and Momordicoside B.
