Isolindleyin

Isolindleyin
Product Name Isolindleyin
CAS No.: 87075-18-1
Catalog No.: CFN93016
Molecular Formula: C23H26O11
Molecular Weight: 478.45 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The herbs of Rheum palmatum L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Price:
Reference standards.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • Phytomedicine.2019, 65:153089
  • World J Mens Health.2019, 10.5534
  • Nat Prod Sci.2014, 20(3):182-190
  • Molecules.2022, 27(2):451.
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • Redox Biology2024, 103197.
  • Arabian Journal of Chemistry2024, 17(3):105648
  • Food Sci Nutr.2019, 8(1):246-256
  • Molecules.2018, 23(7):E1659
  • Adv. Anim. Vet. Sci.2024, 12(5):986-993.
  • Roemerine

    Catalog No: CFN91019
    CAS No: 548-08-3
    Price: $318/5mg
    Glaucine

    Catalog No: CFN90408
    CAS No: 475-81-0
    Price: $188/20mg
    L-Phenylalanine

    Catalog No: CFN93152
    CAS No: 63-91-2
    Price: $30/20mg
    20-O-Glucoginsenoside Rf

    Catalog No: CFN95036
    CAS No: 68406-27-9
    Price: $318/5mg
    Gomisin N

    Catalog No: CFN90125
    CAS No: 69176-52-9
    Price: $218/20mg
    Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1055-61.
    Prolyl endopeptidase inhibitory activity of fourteen Kampo formulas and inhibitory constituents of Tokaku-joki-to.[Pubmed: 10923840]
    Prolyl endopeptidase (PEP, EC 3.4.21.26) is an enzyme playing a role in the metabolism of proline-containing neuropeptides which have been suggested to be involved in learning and memory processes.
    METHODS AND RESULTS:
    In screening for PEP inhibitors from fourteen traditional Kampo formulas, we found that Tokaku-joki-to shows a significant inhibitory activity. Examination of the constituents of the Kampo formula resulted in the isolation of two new compounds, cis-3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside (10) and 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(6-O-galloyl-2-O-cinnamoyl)glucopyranoside (16), along with twenty-five known compounds, cinnamic acid (1), protocatechuic acid (2), gallic acid (3), torachrysone 8-O-beta-D-glucoside (4), emodin (5), emodin 8-O-beta-D-glucoside (6), 3,5,4'-trihydroxystilbene 4'-O-beta-D-glucopyranoside (7), 3,5,4'-trihydroxystilbene 4'-O-beta-D-(2-O-galloyl)glucopyranoside (8), 3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside (9), 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-glucopyranoside (11), Isolindleyin (12), lindleyin (13), 4(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2,6-di-O-galloyl)glucopyranoside (14), 4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside (15), 1-O-galloylglucose (17), 1,2,6-tri-O-galloylglucose (18), gallic acid 4-O-beta-D-(6-O-galloyl)glucopyranoside (19), liquiritigenin (20), liquiritigenin 4'-O-beta-D-glucoside (21), liquiritigenin 7,4'-diglucoside (22), liquiritigenin 4'-O-beta-D-apiofuranosyl-(1-->2)-beta-D-glucopyranoside (23), licuroside (24), (-)-epicatechin (25), (-)-epicatechin 3-O-gallate (26) and (+)-catechin (27).
    CONCLUSIONS:
    Among these compounds, twelve (7-10, 14-16, 18, 19, 24-26) showed noncompetitive inhibition with an IC50 of 22.9, 3.0, 14.9, 2.8, 10.5, 0.69, 8.2, 0.44, 9.39, 26.5, 28.1 and 0.052 microM, respectively.
    Zhongguo Zhong Yao Za Zhi. 2017 Dec;42(23):4514-4519.
    Simultaneous content determination of 14 components in Rhei Radix et Rhizoma by high performance liquid chromatography method.[Pubmed: 29376246]

    METHODS AND RESULTS:
    To establish an HPLC (high performance liquid chromatography) method for the simultaneous content determination of gallic acid, (+)-catechin, (-)-epicatechin-3-O-gallate, Isolindleyin, 4-(4'-hydroxyphenyl)-2-butanone, emodin, chrysophanol, physcion, aloe-emodin, rhein, lindleyin, 4-(4'-hydroxyphenyl)-2-butanone-4'-O-β-D-(2″-O-galloyl-6″-O-cinnamoyl)-glucopyranoside, sennoside A and sennoside B in Rhei Radix et Rhizoma. The analysis was performed on Agilent Zorbax SB-C₁₈ (4.6 mm×150 mm, 5 μm) with 0.05% phosphoric acid solution (A) - acetonitrile (B) as mobile phase for gradient elution. The flow rate was 1 mL•min⁻1, with column temperature of 40 ℃ and the wavelength was set at 268 nm. All calibration curves showed good linearity (r > 0.999 9) within the concentration range. Both the intra- and inter-day precision for 14 analytes was less than 3.1%, with the mean recovery at the range of 91.80%-104.1%. Meanwhile, quantitative determination was carried out for 10 qualified samples from Rheum palmatum and 10 qualified samples from R. tanguticum, respectively. It was found that the content of 4-(4'-hydroxyphenyl)-2-butanone and aloe-emodin were higher in the R. tanguticum and R. palmatum, respectively, and the content of all the compounds was different in each sample.
    CONCLUSIONS:
    The established HPLC method for simultaneous content determination of 14 compounds from Rhei Radix et Rhizoma could be used for quantitative assessment and quality control of Rhei Radix et Rhizoma.
    Poricoic acid G

    Catalog No: CFN95056
    CAS No: 415724-84-4
    Price: $318/5mg
    2''-O-acetylsaikosaponin A

    Catalog No: CFN95085
    CAS No: 102934-42-9
    Price: $318/5mg
    Silychristin B

    Catalog No: CFN95160
    CAS No: 879325-58-3
    Price: $318/5mg
    3',5-Dihydroxy-4',6,7-trimethoxyflavanone

    Catalog No: CFN95316
    CAS No: 90850-99-0
    Price: $318/5mg
    Batatasin IV

    Catalog No: CFN95319
    CAS No: 60347-67-3
    Price: $318/5mg
    Cuscutamine

    Catalog No: CFN95323
    CAS No: 122170-93-8
    Price: $318/5mg
    Narirutin 4'-glucoside

    Catalog No: CFN95421
    CAS No: 17257-22-6
    Price: $318/10mg
    Annphenone

    Catalog No: CFN95426
    CAS No: 61775-18-6
    Price: $318/10mg
    Massonianoside D

    Catalog No: CFN95500
    CAS No: 85115-04-4
    Price: $318/10mg
    Methyl ganoderate D

    Catalog No: CFN95581
    CAS No: 97210-12-3
    Price: $318/5mg