Isocucurbitacin B

Isocucurbitacin B
Product Name Isocucurbitacin B
CAS No.: 17278-28-3
Catalog No.: CFN91003
Molecular Formula: C32H46O8
Molecular Weight: 558.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Cucumis melo
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $288/10mg
Isocucurbitacin B has significantly activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73uM.
Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
  • ACS Food Sci. Technol.2023, 3(2):273-282.
  • Antioxidants.2022, 11(4), 67.
  • Analytical methods2019, 11(6)
  • Molecules.2023, 28(8):3474.
  • Molecules.2023, 28(10):4062.
  • Int J Pharmacol2020, 16:1-9
  • FEBS J.2022, 10.1111:febs.16676.
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • J Applied Biological Chemistry2021, 64(2):185-192
  • Eur J Pharmacol.2023, 951:175770.
  • Cucurbitacin E-2-O-beta-D-glucopyranoside

    Catalog No: CFN91451
    CAS No: 1398-78-3
    Price: Inquiry(manager@chemfaces.com)
    Cucurbitacin S

    Catalog No: CFN90535
    CAS No: 60137-06-6
    Price: Inquiry(manager@chemfaces.com)
    Deoxocucurbitoside B

    Catalog No: CFN91449
    CAS No: 101021-06-1
    Price: Inquiry(manager@chemfaces.com)
    Tetrahydroisocucurbitacin I

    Catalog No: CFN92892
    CAS No: 3877-89-2
    Price: Inquiry(manager@chemfaces.com)
    Cucurbitacin IIA

    Catalog No: CFN98171
    CAS No: 58546-34-2
    Price: $118/20mg
    Cucurbitacin Q1

    Catalog No: CFN91760
    CAS No: 99530-82-2
    Price: $318/10mg
    Cucurbitacin R

    Catalog No: CFN92895
    CAS No: 55903-92-9
    Price: Inquiry(manager@chemfaces.com)
    Dihydrocucurbitacin B

    Catalog No: CFN92140
    CAS No: 13201-14-4
    Price: $318/10mg
    Fabacein

    Catalog No: CFN91586
    CAS No: 37710-13-7
    Price: Inquiry(manager@chemfaces.com)
    Arvenin II

    Catalog No: CFN92896
    CAS No: 65247-28-1
    Price: Inquiry(manager@chemfaces.com)
    J Ethnopharmacol. 2015 Jul 1;169:18-23.
    Bioassay-guided isolation and identification of cytotoxic compounds from Bolbostemma paniculatum.[Pubmed: 25882313 ]
    Four cucurbitacine triterpenoid sapogenins, Isocucurbitacin B(1), 23,24-dihydroIsocucurbitacin B(2), cucurbitacin E(3), 23,24-dihydrocucurbitacin E(4), and 11 triterpenoid saponins, tubeimosideI(5), tubeimoside III(6), tubeimoside V(7), dexylosyltubeimoside III(8), lobatoside C(9), tubeimoside A(10), tumeimoside B(11), lobatoside A(12), tubeimoside C(13), tubeimoside IV(14), 7β,18,20,26-tetrahydroxy-(20S)-dammar-24E-en-3-O-α-L-(4-acetyl)arabinopyranosyl-(1→2)-β-D-glucopyranoside(15) were isolated from the active EtOAc and n-BuOH extracts.
    METHODS AND RESULTS:
    Of them, compounds 2, 4, 9 and 12 were firstly isolated from the Bolbostemma genus. MTT assay revealed that compounds 1, 3 and 4 had significantly activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73μM. It is worth mentioning that compound 4׳s activities against the two cell lines are 12- and 8-fold that of the positive control drug (5-Fu). Whereas, the cyclic bisdesmosides 5-9 exerted significantly activities on BGC-823, HeLa, HT-29 and MCF-7 cancer cells with IC50 values ranging from 1.30 to 15.64μM. And 6׳s activities against the four cell lines are 6-, 3-, 10- and 16-fold that of 5-Fu and 8׳s activities against the four cell lines are 5-, 3-, 14- and 9-fold that of 5-Fu.
    CONCLUSIONS:
    The cytotoxic activity of the bulbs of B. paniculatum is mainly ascribable to cucurbitacine triterpenoid sapogenins (1-4) and the cyclic bisdesmosides (5-9). The cyclic bisdesmosides are the main anti-cancer active compounds of B. paniculatum. The above results provide scientific evidence to support, to some extent, the ethnomedicinal use of B. paniculatum as anticancer remedies in traditional Chinese medicine.
    8,8''-Bibaicalein

    Catalog No: CFN95007
    CAS No: 135309-02-3
    Price: $318/5mg
    Iristectorin A

    Catalog No: CFN95037
    CAS No: 37744-61-9
    Price: $318/20mg
    Physalin O

    Catalog No: CFN95097
    CAS No: 120849-18-5
    Price: $413/5mg
    Dehydrojuncusol

    Catalog No: CFN95143
    CAS No: 117824-04-1
    Price: $318/5mg
    Momordicoside X

    Catalog No: CFN95170
    CAS No: 1333321-50-8
    Price: $368/5mg
    Ginsenoside MC

    Catalog No: CFN95232
    CAS No: 175484-06-7
    Price: $318/10mg
    Quasipanaxatriol

    Catalog No: CFN95248
    CAS No: 171903-78-9
    Price: $413/5mg
    Somnifericin

    Catalog No: CFN95280
    CAS No: 173693-57-7
    Price: $318/5mg
    Eriodictyol 7-O-glucuronide

    Catalog No: CFN95290
    CAS No: 125535-06-0
    Price: $318/10mg
    Maingayone B

    Catalog No: CFN95483
    CAS No: 1071223-57-8
    Price: $318/20mg