Heteroclitin D
Heteroclitin D may be a valuable antitumor promoter or chemopreventor. Heteroclitin D can inhibit L-type calcium channels.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Acta Pharmacol Sin. 2000 Apr;21(4):373-6.
Blocking effects of heteroclitin D and gomisin J on L-type calcium channels in ventricular cells of guinea pig.[Pubmed:
11324471]
To study the effects of Heteroclitin D (HD) and gomisin J (GJ), two lignans from Kadsura medicinal plants, on L-type calcium channels in ventricular cells of guinea pig.
METHODS AND RESULTS:
The calcium currents were measured by whole-cell patch-clamp recording technique. HD 1 and 10 mumol/L decreased the L-type calcium current from (770 +/- 155) to (482 +/- 104) and (384 +/- 85) pA, respectively. GJ 10 mumol/L inhibited calcium current from (822 +/- 169) to (436 +/- 143) pA. Neither HD nor GJ affected the steady-state activation curve. But they had impact on steady-state inactivation curve. HD 10 mumol/L changed the half inactivation voltage (V0.5) from -22.7 to -40.9 mV, and slope factor (kappa) from 10.2 to 20.6 (n = 4 cells from 3 guinea pigs, P < 0.05). GJ 10 mumol/L changed the V0.5 from -17.7 to -33.3 mV, and kappa from 15.9 to 27.8 (n = 5 cells from 3 guinea pigs, P < 0.05).
CONCLUSIONS:
HD and GJ inhibited L-type calcium channels.
J Nat Prod. 2002 Sep;65(9):1242-5.
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.[Pubmed:
12350139]
METHODS AND RESULTS:
Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), Heteroclitin D (6), kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells.
Neokadsuranin (5) and schisandrin C (9) were the most potent compounds.
CONCLUSIONS:
These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.
