Gentiside J
Gentiside J is a potent inducer of neurite outgrowth on PC12 cells.
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Nutr Cancer.2022, 1-13.
Biomed Pharmacother.2020, 125:109784.
Evid Based Complement Alternat Med.2018, 2018:3610494
Journal of Functional Foods2024, 116:106186
J Food Biochem.2019, 43(9):e12970
Phytomedicine.2022, 100:154036.
Molecules.2024, 29(5):1050.
Journal of Oil Palm Research2019, 31(2):238-247
Int. J. Mol. Sci. 2022, 23(3),1696.
Molecules.2021, 26(4):816.
Related and Featured Products
Bioorg Med Chem. 2010 Oct 1;18(19):6995-7000.
Gentisides C-K: nine new neuritogenic compounds from the traditional Chinese medicine Gentiana rigescens Franch.[Pubmed:
20813533 ]
Nine new alkyl 2,3-dihydroxybenzoates, gentisides C-K(gentiside C,gentiside D, gentiside E, gentiside F,gentiside G, gentiside H, gentiside I, Gentiside J, gentiside K), were isolated from the traditional Chinese medicine Gentiana rigescens Franch.
METHODS AND RESULTS:
Their structures and stereochemistry were elucidated by spectroscopic methods, and comparison of the specific rotation with that of the gentiside B. These metabolites are additional members of the gentisides which belong to a novel class of neuritogenic compounds. They are structurally different from one another because they possess varying alkyl chain lengths, with or without an isobutyl or isopropyl group at the end of the alkyl chain. These compounds are potent inducers of neurite outgrowth on PC12 cells. The gentiside C possessing the shortest alkyl chain length exhibited the highest neuritogenic activity among all of the gentisides. Gentiside C showed a significant neuritogenic activity at 1 μM against PC12 cells comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL. In addition, evident neuritogenic activity was observed in the cells when treated with gentiside C at a concentration as low as 0.03 μM.
CONCLUSIONS:
The structure-activity relationships within the gentisides A-K revealed that alkyl chain length is important for the activity, but structure diversity at the end of the alkyl chain is not.
