Gentiside J | CAS:1238837-50-7 | Manufacturer ChemFaces

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Gentisides C-K: nine new neuritogenic compounds from the traditional Chinese medicine Gentiana rigescens Franch.[Pubmed: 20813533 ]

Nine new alkyl 2,3-dihydroxybenzoates, gentisides C-K(gentiside C,gentiside D, gentiside E, gentiside F,gentiside G, gentiside H, gentiside I, Gentiside J, gentiside K), were isolated from the traditional Chinese medicine Gentiana rigescens Franch.
METHODS AND RESULTS:
Their structures and stereochemistry were elucidated by spectroscopic methods, and comparison of the specific rotation with that of the gentiside B. These metabolites are additional members of the gentisides which belong to a novel class of neuritogenic compounds. They are structurally different from one another because they possess varying alkyl chain lengths, with or without an isobutyl or isopropyl group at the end of the alkyl chain. These compounds are potent inducers of neurite outgrowth on PC12 cells. The gentiside C possessing the shortest alkyl chain length exhibited the highest neuritogenic activity among all of the gentisides. Gentiside C showed a significant neuritogenic activity at 1 μM against PC12 cells comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL. In addition, evident neuritogenic activity was observed in the cells when treated with gentiside C at a concentration as low as 0.03 μM.
CONCLUSIONS:
The structure-activity relationships within the gentisides A-K revealed that alkyl chain length is important for the activity, but structure diversity at the end of the alkyl chain is not.

Product Name	Gentiside J
CAS No.:	1238837-50-7
Catalog No.:	CFN89004
Molecular Formula:	C₂₉H₅₀O₄
Molecular Weight:	462.71 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Targets:	NGF
Source:	The whole plants of Gentiana rigescens Franch.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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