Dehydroandrographolide succinate
Dehydroandrographolide succinate can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS. It combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly.
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Anhui Medical Journal, 2010.
Therapeutic effects of dehydroandrographolide succinate combined with ribavirin on children with hand-foot-and-mouth disease[Reference:
WebLink]
To evaluate the therapeutic effects of Dehydroandrographolide succinate and ribavirin on children with the early severe tendencies of hand-foot-and-mouth disease.
METHODS AND RESULTS:
Children(46 cases) with the early tendencies of hand-foot-and-mouth disease were divided randomly into two groups.All cases received ribavirin and therapies based on their symptoms,while the treatment group of 23 children received Dehydroandrographolide succinate(10 mg.kg-1.d-1) for 5 days.Clinical symptom regression time or recovery time in two groups were observed after treatments. All children were recovered after treatments and no case develop into neurogenic pulmonary edema or cardiopulmonary collapse.The duration of fever was shorter in the treatment group;rashes on hands and feet faded more quickly than those of the control group.The difference between the two groups had statistical significance.However,there was no statistically significant differences between the two groups as for the time of mental improvement,disappearance of body shaking and hospital stay time.
CONCLUSIONS:
Dehydroandrographolide succinate combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly.
Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41.
Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS.[Pubmed:
22985554]
To investigate the effect of Dehydroandrographolide succinate (DAS) on oxidative stress and induced nitric oxide synthase (iNOS) expression in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury.
METHODS AND RESULTS:
Thirty male BALB/C mice were randomly divided into control group, LPS+DAS group and LPS group (n=10). The levels of interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), malondialdehyde (MDA) and superoxide dismutase (SOD) in the bronchoalveolar lavage fluid (BALF) were measured. The wet-to-dry ratio (W/D) of the lung tissue was determined to evaluate lung edema. HE staining was used to observe the pathological changes and lung injury scores. The expressions of iNOS mRNA and protein in the lungs were analyzed using RT-PCR and Western blotting, respectively.
IL-1β, IL-6, TNF-α and MDA levels in the BALF, W/D, lung injury scores, and iNOS mRNA and protein expressions increased and SOD in the BALF decreased significantly after intratracheal LPS injection. Compared with those in LPS group, IL-1β, IL-6, TNF-α and MDA in BALF, W/D, lung injury scores and iNOS mRNA and protein expression were significantly reduced and SOD in the BALF significantly increased in LPS+DAS group.
CONCLUSIONS:
Dehydroandrographolide succinate can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.
