Coccinic acid
Coccinic acid shows inhibitory effects against colorectal carcinoma HCT-15 and oral epithelial cell line KB-3-1.Mixture of coccinic acid and anwuweizonic acid shows significant inhibitory activity against human decidual cells and rat luteal cells in vitro, suggests that it has antifertility activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Pharm Biol. 2013 Sep;51(9):1204-7.
Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens.[Pubmed:
23883077]
METHODS AND RESULTS:
Nine known compounds were obtained, including four lignans, epischisandrone (1), tigloylgomisin P (2), cagayanone (3) and (-)-gomisin L₂ (4), together with five triterpenoids, micranoic acid B (5), lancifodilactone H (6), Coccinic acid (7), schisanlactone B (8) and anwuweizonic acid (9).
CONCLUSIONS:
Compounds 2-6 and 8 showed moderate to marginal cytotoxicity, with GI₅₀ values of 11.83-35.65 μM.
Chinese Journal of Modern Applied Pharmacy, 2002, 19(2):103-5.
Antifertility Triterpenoid Acids from Kadsura angustifolia.[Reference:
WebLink]
To isolate and characterize bioactive compounds from the stems of Kadsura angustifolia .
METHODS AND RESULTS:
The compounds were extracted with solvent,isolated by column chromatography and identified by the spectroscopic methods. eight compounds and a mixture of two triterpenoid acids were isolated and identified as epi anwuweizic acid (1),shikimic acid (2),(+) catechin (3),poriferast 5 en 3β,7α diol (4),β sitosterol (5),daucosterol (6),cerotic acid 1 monoglyceride (7) and behenic acid 1 monoglyceride (8),and mixiture of Coccinic acid (9) and anwuweizonic acid (10).
CONCLUSIONS:
Mixture of 9 and 10 showed significant inhibitory activity against human decidual cells and rat luteal cells in vitro . Compounds 2~4,7 and 8 were first reported in the family Schisandraceae,and compounds 1,5,6,9 and 10 were isolated from K.angustifolia for the first time.
Planta Med. 1986 Dec;(6):492-3.
Triterpenoids from Roots and Stems of Kadsura coccinea.[Pubmed:
17345419]
METHODS AND RESULTS:
24-Methylenecycloartenone ( 1), kadsuric acid ( 2) and a new triterpenoid acid named Coccinic acid ( 3A) were isolated from the ether soluble fraction of the dried roots and stems of Kadsura coccinea.
