Artoheterophyllin B
Artoheterophyllin B has antiplasmodial activity.
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Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to
24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
BMC Complement Altern Med.2014, 14:242
Korean J. Food Sci. & Technol.2022, 54(2):241-246
Environ Toxicol.2023, tox.23999.
J Appl Biol Chem.2022, 65(4):pp.463-469.
Front Pharmacol.2022, 13:919230.
Chemistry of Natural Compounds2018, 204-206
Environ Toxicol Pharmacol.2019, 66:109-115
Biochem Biophys Res Commun.2020, 522(4):1052-1058
Separations2023, 10(4), 231.
J of Physics Conference Series2019, 1349(1)
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Planta Med. 2010 Oct;76(14):1600-4.
Antiplasmodial, antitrypanosomal, and cytotoxic activities of prenylated flavonoids isolated from the stem bark of Artocarpus styracifolius.[Pubmed:
20379954]
METHODS AND RESULTS:
The ethyl acetate extract obtained from the stem bark of ARTOCARPUS STYRACIFOLIUS (Moraceae) exhibited strong antiplasmodial activity (87 % at 10 µg/mL) whereas weak cytotoxicity was observed in a human fibroblast cell line (MRC-5). Phytochemical investigation of this extract led to isolation of two new prenylated flavonoids, styracifolins A and B ( 1 and 2), as well as the known artoheterophyllin A ( 3), Artoheterophyllin B ( 4), artonins A ( 5), B ( 6), and F ( 7), and heterophyllin ( 8). Structures of 1 and 2 were elucidated by spectroscopic methods and through comparison with data reported in the literature.
CONCLUSIONS:
Compounds 1- 8 exhibited antiplasmodial activities with IC (50) values ranging from 1.1 µM to 13.7 µM, and compounds 1, 2, 6, and 8 showed significant antitrypanosomal activities.
