Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q–S (compounds 3–5), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A (9) were isolated from the stem bark of Daphniphyllum macropodum.
Daphniphyllum macropodum is a shrub or small tree found in China, Japan and Korea. Like all species in the genus Daphniphyllum, D. macropodum is dioecious, that is male and female flowers are borne on different plants. The timber is used in China in construction and furniture making.[1] It is grown as an ornamental plant, chiefly for its foliage. Daphniphyllum macropodum, like other species in the genus, can be grown as an ornamental evergreen shrub or small tree, when its main attractions are its large leaves and pink-flushed new growth. A sheltered situation in moist but well-drained soil is recommended. The newly emerged shoots are easily damaged by frost.