Inhibitors

5'-S-Methyl-5'-thioadenosine
Catalog No: CFN98265

S-Methyl-5′-thioadenosine can inhibit the activity of ThiC (4-amino-5-hydroxymethyl-2- methylpyrimidine phosphate synthase).

3-Geranyl-4-methoxybenzoic acid
Catalog No: CFN98266

3-Geranyl-4-methoxybenzoic acid exhibits stronger inhibition effect on the activation of hyaluronidase than that of tranilast.

(-)-Epiafzelechin
Catalog No: CFN98271

(-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema, it exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. (-)-Epicatechin shows zero and/or the lowest activities against pancreatic lipase (IC50 > 20 microM). Epiafzelechin has antioxidant properties.

D-Menthol
Catalog No: CFN98125

Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes, it attenuates α7 mediated Ca 2+ transients in the cell body and neurite, suggests that menthol inhibits α7-nACh receptors in a noncompetitive manner. Menthol has cooling sensation in the skin, by chemically triggering the cold-sensitive TRPM8 receptors. Menthol has analgesic property, it acts as a noncompetitive antagonist of the 5-HT3 receptor.

(+)-Afzelechin
Catalog No: CFN98280

(+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM; it also shows moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH) and improves the reduced glutathione levels in rat pancreatic homogenate.(+)-Afzelechin has inhibitory compound of alpha-glucosidase activity, the ID(50) (50% inhibition dose) value is 0.13 mM.