GABA(A) receptor blockers

(+)-Bicuculline
Catalog No: CFN99748

(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.It is effective in vitro against spore germination of some plant pathogenic fungi, it can significantly inhibit spore germination of all the fungi at concentrations of 100-1000 ppm.
(-)-Bicuculline methochloride
Catalog No: CFN92860

(-)-Bicuculline methochloride is a GABAA-receptor antagonist. Exposure to 100 microM (-)-Bicuculline methochloride for 48 hr can result in prominent CA1 cell death.