Antileukaemic

Daphnoretin
Catalog No: CFN90329

Daphnoretin has strong antiviral activity, mainly on the later phase of the replication cycle. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through promoting apoptosis in a mitochondria-mediated way; it causes death of HOS cells by blocking cells successively in G2/M phases and activating the caspase-3 pathway.

Lappaconitine Hydrobromide
Catalog No: CFN90361

Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias, it is a selective blocker of the TTX-sensitive Na+ channels, and does not influence on the activation threshold of Na+ channels. Lappaconitine hydrobromide can be used for local anesthesia, and analgesic treatment. Lappaconitine hydrobromide has anti-inflammatory effects, it can remove inflammation and swelling, lower temperature and relieve heat.

14-Deoxy-11-hydroxyandrographolide
Catalog No: CFN97815

14-Deoxy-11-hydroxyandrographolide shows potent cell differentiation-inducing activity towards mouse myeloid leukemia (M1) cells.

12-O-Tiglylphorbol-13-isobutyrate
Catalog No: CFN90368

12-O-Tetradecanoylphorbol-13-acetate has cytotoxic against in vitro P-388 lymphocytic leukemia and KB nasopharyngeal carcinoma cell.

Plumbagin
Catalog No: CFN90444

Plumbagin, a potential natural FOXM1 inhibitor, has anticancer, and anti-fibrotic activies, it inactivates the NF-κB/TLR-4 pathway that is associated with inflammatory reactions, thereby mitigating liver fibrosis. Plumbagin offers significant protective role against DEX-induced cellular damage via regulating oxidative stress, apoptosis, and osteogenic markers.