Anticholinesterase

Tropacocaine
Catalog No: CFN00219

Tropacocaine has cardiovascular effects.Tropacocaine inhibits norepinephrine uptake at the concentration of 30 microM. Tropacocaine has antimuscarinic activity, it can attenuate the oxotremorine-induced inhibition of the release of acetylcholine, it can inhibit the spontaneous and veratridine-induced release of newly synthesized acetylcholine, but not via activation of presynaptic muscarinic receptors.

beta-Amyrone
Catalog No: CFN97099

beta-Amyrone has antifungal activity, it also shows a moderate activity against Chikungunya virus replication (EC50 =86 uM). beta-Amyrone exhibits anti-α-glucosidase inhibitory activity and moderate anti- acetylcholinesterase (AChE) activity.

Hyoscyamine
Catalog No: CFN00232

Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM, it is widely used in medicine due to its anticholinergic activity. Hyoscyamine could be used to reduce abdominal discomfort and colonic spasm during a barium enema.

Heleurine
Catalog No: CFN00239

Heleurine, platyphylline, supinine and cynaustraline are more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine.

Xanthoplanine
Catalog No: CFN97169

Xanthoplanine fully inhibits the EC(50) ACh responses of both alpha7 and alpha4beta2 nACh receptors with estimated IC(50) values of 9+/-3 microM (alpha7) and 5+/-0.8 microM (alpha4beta2).